Epithelial–mesenchymal transition markers in malignant ovarian germ cell tumors

Olesya Solheim, Mette Førsund, Claes G. Tropé, Sigrid Marie Kraggerud, Jahn M. Nesland, Ben Davidson

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    2 Scopus citations

    Abstract

    The purpose of this study was to determine the expression and potential clinical role of epithelial-to-mesenchymal transition (EMT)-related factors in malignant ovarian germ cell tumors (MOGCT). Protein expression of E-cadherin, N-cadherin, P-cadherin, Zeb1, HMGA2, and vimentin by immunohistochemistry was analyzed in 42 MOGCT from patients treated in Norway during the period 1981–2001. Expression was analyzed for association with clinicopathologic parameters. E-cadherin (p = 0.016) and HMGA2 (p = 0.002) expression was significantly higher in immature teratomas and yolk sac tumors compared with dysgerminomas. Vimentin (p < 0.001) and Zeb1 (p = 0.029) staining was significantly higher in immature teratomas compared with yolk sac tumors and dysgerminomas, whereas no significant differences were observed for N-cadherin and P-cadherin. EMT-associated markers were not significantly related to clinicopathologic parameters including age, tumor diameter, and FIGO stage. In conclusion, based on this limited series, EMT-associated markers are not associated with clinical parameters in MOGCT, in contrast to ovarian carcinoma. EMT-related proteins are differentially expressed among various MOGCT subtypes, suggesting differences in biological characteristics associated with invasion and metastasis.

    Original languageEnglish (US)
    Pages (from-to)781-786
    Number of pages6
    JournalAPMIS
    Volume125
    Issue number9
    DOIs
    StatePublished - Sep 2017

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    Keywords

    • Ovary
    • epithelial-to-mesenchymal transition
    • immunohistochemistry
    • malignant germ cell tumor
    • tumor progression

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Immunology and Allergy
    • Microbiology (medical)

    Cite this

    Solheim, O., Førsund, M., Tropé, C. G., Kraggerud, S. M., Nesland, J. M., & Davidson, B. (2017). Epithelial–mesenchymal transition markers in malignant ovarian germ cell tumors. APMIS, 125(9), 781-786. https://doi.org/10.1111/apm.12715