TY - JOUR
T1 - Epstein–Barr virus-associated B-cell lymphoproliferative disorders and lymphomas
T2 - a review
AU - Marques-Piubelli, Mario L.
AU - Salas, Yessenia I.
AU - Pachas, Carlos
AU - Becker-Hecker, Renato
AU - Vega, Francisco
AU - Miranda, Roberto N.
N1 - Publisher Copyright:
© 2019 Royal College of Pathologists of Australasia
PY - 2020/1
Y1 - 2020/1
N2 - In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified—virus detection is required for the diagnosis, while in others its detection is not necessary for diagnosis. EBV infection has three main latency patterns (types III, II, and I). Different latency patterns are found in different LPD types and are related to the host immune system status. For each of the LPDs/lymphomas, we discuss the clinical presentation, epidemiology, pathology, immunophenotype, and genetic or molecular basis. We provide data for a better understanding of the relationships among the discussed diseases and other information that can be useful in differential diagnosis. Not included in this review are classic Hodgkin lymphoma and some specific variants of DLBCL, as these entities are discussed in separate reviews in this issue.
AB - In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified—virus detection is required for the diagnosis, while in others its detection is not necessary for diagnosis. EBV infection has three main latency patterns (types III, II, and I). Different latency patterns are found in different LPD types and are related to the host immune system status. For each of the LPDs/lymphomas, we discuss the clinical presentation, epidemiology, pathology, immunophenotype, and genetic or molecular basis. We provide data for a better understanding of the relationships among the discussed diseases and other information that can be useful in differential diagnosis. Not included in this review are classic Hodgkin lymphoma and some specific variants of DLBCL, as these entities are discussed in separate reviews in this issue.
KW - B-cell lymphoma
KW - Epstein–Barr virus
KW - HHV-8
KW - HIV
KW - diffuse large B-cell lymphoma
KW - fibrin-associated large cell lymphoma
KW - iatrogenic immunodeficiency
KW - immunodeficiency
KW - large cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85075402094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075402094&partnerID=8YFLogxK
U2 - 10.1016/j.pathol.2019.09.006
DO - 10.1016/j.pathol.2019.09.006
M3 - Review article
C2 - 31706670
AN - SCOPUS:85075402094
SN - 0031-3025
VL - 52
SP - 40
EP - 52
JO - Pathology
JF - Pathology
IS - 1
ER -