Abstract
Candida auris is a rapidly spreading virulent pathogen frequently resistant to multiple antifungal drugs that can form biofilms and infect wounds. Hence, there is a need for C. auris wound treatments not posing risks for developing antifungal resistance. We tested the ability of a polygalacturonic and caprylic acid ointment (PG+CAP) to rapidly eradicate C. auris biofilms within 2-hour exposures in an in vitro model. Medical-grade honey (MediHoney) wound ointment was used as a comparator. Nine different C. auris strains were tested. PG+CAP eradicated biofilms of 8 of the 9 tested strains and produced a > 5-log10 reduction of the ninth. MediHoney produced reductions ranging from 2 to 4 log10 without fully eradicating any strains. The differences between PG+CAP and MediHoney were statistically significant (p < 0.05). These results suggest that PG+CAP is a promising antimicrobial ointment warranting further in vivo study in wounds which may be colonized by C. auris biofilms.
Original language | English (US) |
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Article number | 101519 |
Journal | Journal of Medical Mycology |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2024 |
Keywords
- Biofilm eradication
- Candida auris
- Caprylic acid
- Polygalacturonic acid
- Wound ointment
ASJC Scopus subject areas
- Infectious Diseases