Eradication of Candida auris biofilm in vitro by a polygalacturonic and caprylic acid wound ointment

Y. Lan Truong, Joel Rosenblatt, Bahgat Gerges, Ying Jiang, Issam Raad

Research output: Contribution to journalArticlepeer-review

Abstract

Candida auris is a rapidly spreading virulent pathogen frequently resistant to multiple antifungal drugs that can form biofilms and infect wounds. Hence, there is a need for C. auris wound treatments not posing risks for developing antifungal resistance. We tested the ability of a polygalacturonic and caprylic acid ointment (PG+CAP) to rapidly eradicate C. auris biofilms within 2-hour exposures in an in vitro model. Medical-grade honey (MediHoney) wound ointment was used as a comparator. Nine different C. auris strains were tested. PG+CAP eradicated biofilms of 8 of the 9 tested strains and produced a > 5-log10 reduction of the ninth. MediHoney produced reductions ranging from 2 to 4 log10 without fully eradicating any strains. The differences between PG+CAP and MediHoney were statistically significant (p < 0.05). These results suggest that PG+CAP is a promising antimicrobial ointment warranting further in vivo study in wounds which may be colonized by C. auris biofilms.

Original languageEnglish (US)
Article number101519
JournalJournal of Medical Mycology
Volume34
Issue number4
DOIs
StatePublished - Dec 2024

Keywords

  • Biofilm eradication
  • Candida auris
  • Caprylic acid
  • Polygalacturonic acid
  • Wound ointment

ASJC Scopus subject areas

  • Infectious Diseases

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