Erratum: Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemoand radio-sensitivity in nasopharyngeal carcinoma (PLoS ONE (2013) 8:1 (e54565) DOI: 10.1371/journal.pone.0054565)

Yunbao Pan, Fuling Zhou, Ronghua Zhang, Francois X. Clar

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

After publication of this article [1], concerns were raised that the bands in Fig 4C corresponding to PARP from HONE1 NPC cells appear similar to bands in the panel representing PARP from C666-1 NPC cells. The authors clarified that, when preparing the manuscript, the raw data from the C666-1 experiment was mistakenly included in both the C666-1 and HONE1 panels. With this notice, the authors provide an updated Fig 4, along with an original blot image underlying the panels which were originally of concern (in Supporting Information S1 File). A PLOS ONE Editorial Board member reviewed the updated figure and underlying data and confirmed that they support the results and conclusions reported in the original article. At the time of publication of this notice, the underlying data for the rest of Fig 4 and the other figures in the article are not available. In addition, concerns have been noted for three of the cell lines used in this study. The CNE-1 and CNE-2 cell lines have been reported as contaminated with HeLa and highly similar to one another [2, 3]. After publication of this article [1], the HONE-1 line was also reported as potentially contaminated with HeLa cells [3]. A further cell line, the Epstein-Barr virus-positive line C666-1, was also used in the study. In light of these issues, there may be limited generalizability of the findings as representative of nasopharyngeal carcinoma biology. The authors apologize for the errors in the published article. PLOS ONE apologizes for our delay in posting this Correction and acknowledges that the authors responded to the concerns about Fig 4 by providing data and clarifications in 2015.

Original languageEnglish (US)
Article numbere0237943
JournalPloS one
Volume15
Issue number8 August
DOIs
StatePublished - Aug 2020

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General

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