@article{14b09c712ec54d04a65dc059ec960f2b,
title = "Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse",
abstract = "Little is known about how diversified retinal ganglion cell (RGC) subtypes develop. Using genetic and electrophysiological analyses, Kiyama et al. identify Tbr1 expression in two types of morphologically and functionally distinct OFF RGCs. Loss-of-function and gain-of-function studies show Tbr1 regulates the formation and dendritic morphogenesis of these cells.",
keywords = "J-RGC, Jam2, OFF RGC, OFF-sustained RGC, RGC development, RGC subtype, Tbr1, dendritic branching, dendritic morphogenesis",
author = "Takae Kiyama and Ye Long and Chen, {Ching Kang} and Whitaker, {Christopher M.} and Allison Shay and Hongyu Wu and Badea, {Tudor C.} and Amir Mohsenin and Jan Parker-Thornburg and Klein, {William H.} and Mills, {Stephen L.} and Massey, {Stephen C.} and Mao, {Chai An}",
note = "Funding Information: This work was supported by grants from the NIH-National Eye Institute to C.A.-M. (EY024376), C.-K.C. (EY013811, EY026930), C.M.W. (EY021958), W.H.K. (EY011930), S.C.M. (EY006515), and S.L.M. (EY10121). C.A.-M. is indebted to W.H.K. for partial salary support. C.-K.C. is the Alice R. McPherson Retina Research Foundation Endowed Chair at BCM. This work was also supported in part by NEI Vision Core Grants P30EY028102 (UTHealth), P30EY002520 (BCM), and the Hermann Eye Fund (UTHealth). We acknowledge the Genetically Engineered Mouse Facility at UTMDACC for making two Tbr1 mouse lines, the Gene Edit Biolab (Atlanta, GA) for making TetO-Tbr1:eGFP transgenic lines, Ping Pan (UTHealth), Charlie Z. Luo (UTMDACC), Harry Liu (Rice University), and Leila Jamal (Arizona State University) for technical assistance, and Dr. Kimberly Mankiewicz (UTHealth) for manuscript proofreading and editing. C.-A.M. Y.L. C.-K.C. C.M.W. T.C.B. S.L.M. and S.C.M. designed experiments. T.K. Y.L. C.-K.C. C.M.W. A.S. H.W. A.M. S.L.M. S.C.M. and C.-A.M. executed experiments. C.-A.M. and J.P.-T. generated Tbr1 mice. T.C.B. and W.H.K. provided mice and reagents. C.-A.M. C.-K.C. and S.L.M. wrote the paper. The authors declare no competing interests. Funding Information: This work was supported by grants from the NIH-National Eye Institute to C.A.-M. ( EY024376 ), C.-K.C. ( EY013811 , EY026930 ), C.M.W. ( EY021958 ), W.H.K. ( EY011930 ), S.C.M. ( EY006515 ), and S.L.M. ( EY10121 ). C.A.-M. is indebted to W.H.K. for partial salary support. C.-K.C. is the Alice R. McPherson Retina Research Foundation Endowed Chair at BCM. This work was also supported in part by NEI Vision Core Grants P30EY028102 (UTHealth), P30EY002520 (BCM), and the Hermann Eye Fund (UTHealth). We acknowledge the Genetically Engineered Mouse Facility at UTMDACC for making two Tbr1 mouse lines, the Gene Edit Biolab (Atlanta, GA) for making TetO-Tbr1:eGFP transgenic lines, Ping Pan (UTHealth), Charlie Z. Luo (UTMDACC), Harry Liu (Rice University), and Leila Jamal (Arizona State University) for technical assistance, and Dr. Kimberly Mankiewicz (UTHealth) for manuscript proofreading and editing. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = apr,
day = "16",
doi = "10.1016/j.celrep.2019.03.077",
language = "English (US)",
volume = "27",
pages = "900--915.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}