Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review

Janice L. Pasieka; Kelly Wentworth; Caitlin T. Yeo; Serge Cremers; David Dempster; Seiji Fukumoto; Ravinder Goswami; Pascal Houillier; Michael A. Levine; Jesse D. Pasternak; Nancy D. Perrier; Antonio Sitges-Serra; Dolores M. Shoback

doi:10.1002/jbmr.4714

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review

Janice L. Pasieka, Kelly Wentworth, Caitlin T. Yeo, Serge Cremers, David Dempster, Seiji Fukumoto, Ravinder Goswami, Pascal Houillier, Michael A. Levine, Jesse D. Pasternak, Nancy D. Perrier, Antonio Sitges-Serra, Dolores M. Shoback

Surgical Oncology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular, and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy.

Original language	English (US)
Pages (from-to)	2586-2601
Number of pages	16
Journal	Journal of Bone and Mineral Research
Volume	37
Issue number	12
DOIs	https://doi.org/10.1002/jbmr.4714
State	Published - Dec 2022

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

Access to Document

10.1002/jbmr.4714

Cite this

@article{eb29f6246155470aab37e5767e2a4841,

title = "Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review",

abstract = "The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular, and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy.",

author = "Pasieka, {Janice L.} and Kelly Wentworth and Yeo, {Caitlin T.} and Serge Cremers and David Dempster and Seiji Fukumoto and Ravinder Goswami and Pascal Houillier and Levine, {Michael A.} and Pasternak, {Jesse D.} and Perrier, {Nancy D.} and Antonio Sitges-Serra and Shoback, {Dolores M.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).",

year = "2022",

month = dec,

doi = "10.1002/jbmr.4714",

language = "English (US)",

volume = "37",

pages = "2586--2601",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Etiology and Pathophysiology of Hypoparathyroidism

T2 - A Narrative Review

AU - Pasieka, Janice L.

AU - Wentworth, Kelly

AU - Yeo, Caitlin T.

AU - Cremers, Serge

AU - Dempster, David

AU - Fukumoto, Seiji

AU - Goswami, Ravinder

AU - Houillier, Pascal

AU - Levine, Michael A.

AU - Pasternak, Jesse D.

AU - Perrier, Nancy D.

AU - Sitges-Serra, Antonio

AU - Shoback, Dolores M.

PY - 2022/12

Y1 - 2022/12

N2 - The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular, and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy.

AB - The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular, and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy.

UR - http://www.scopus.com/inward/record.url?scp=85142146648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85142146648&partnerID=8YFLogxK

U2 - 10.1002/jbmr.4714

DO - 10.1002/jbmr.4714

M3 - Article

C2 - 36153665

AN - SCOPUS:85142146648

SN - 0884-0431

VL - 37

SP - 2586

EP - 2601

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 12

ER -

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this