Etiology of Waldenström Macroglobulinemia: Genetic Factors and Immune-related Conditions

Elisabet E. Manasanch; Sigurdur Y. Kristinsson; Ola Landgren

doi:10.1016/j.clml.2013.02.002

Etiology of Waldenström Macroglobulinemia: Genetic Factors and Immune-related Conditions

Elisabet E. Manasanch, Sigurdur Y. Kristinsson, Ola Landgren

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.

Original language	English (US)
Pages (from-to)	194-197
Number of pages	4
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2013.02.002
State	Published - Apr 2013
Externally published	Yes

Keywords

Autoimmune disease
Familial aggregation
Immune-related
MYD88 L265P
Susceptibility

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2013.02.002

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title = "Etiology of Waldenstr{\"o}m Macroglobulinemia: Genetic Factors and Immune-related Conditions",

abstract = "Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenstr{\"o}m macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenstr{\"o}m macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.",

keywords = "Autoimmune disease, Familial aggregation, Immune-related, MYD88 L265P, Susceptibility",

author = "Manasanch, {Elisabet E.} and Kristinsson, {Sigurdur Y.} and Ola Landgren",

note = "Funding Information: This research was supported by grants from the Swedish Cancer Society , Stockholm County Council , the Karolinska Institutet Foundations , and the Intramural Research Program of the National Institutes of Health , National Cancer Institute .",

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doi = "10.1016/j.clml.2013.02.002",

language = "English (US)",

volume = "13",

pages = "194--197",

journal = "Clinical Lymphoma, Myeloma and Leukemia",

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publisher = "Cancer Media Group",

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T1 - Etiology of Waldenström Macroglobulinemia

T2 - Genetic Factors and Immune-related Conditions

AU - Manasanch, Elisabet E.

AU - Kristinsson, Sigurdur Y.

AU - Landgren, Ola

N1 - Funding Information: This research was supported by grants from the Swedish Cancer Society , Stockholm County Council , the Karolinska Institutet Foundations , and the Intramural Research Program of the National Institutes of Health , National Cancer Institute .

PY - 2013/4

Y1 - 2013/4

N2 - Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.

AB - Epidemiologic studies provide an insight into the etiology of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, which indicates that repetitive immune stimulation and genetic factors play an important role. Here, the current understanding on the causes of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia are reviewed. Recent studies of the literature are discussed, and future population-based studies are proposed to further elucidate the molecular mechanisms that underlie these associations. Finally, the clinical implications of these data are outlined, and perspectives on clinical follow-up and counseling are provided.

KW - Autoimmune disease

KW - Familial aggregation

KW - Immune-related

KW - MYD88 L265P

KW - Susceptibility

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Etiology of Waldenström Macroglobulinemia: Genetic Factors and Immune-related Conditions

Abstract

Keywords

ASJC Scopus subject areas

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