Evaluation of human acute leukemia data using a murine leukemia model system

Ralph E. Johnson; Marvin Zelen; Emil J. Freireich

doi:10.1002/1097-0142(196604)19:4<481::AID-CNCR2820190404>3.0.CO;2-P

Evaluation of human acute leukemia data using a murine leukemia model system

Ralph E. Johnson, Marvin Zelen, Emil J. Freireich

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Data from studies of the duration of unmaintained remissions in human acute leukemia have been analyzed according to a murine L1210 leukemia model system. The pattern of recurrence follows an exponential distribution. The slope of recurrence (λ) was more shallow and the guarantee time (G) was longer for the intensive combination treatments (VAMP and BIKE) than for single drug treatment (vincristine and prednisone). The presented model provides the clinician with another potential tool for the analysis of the effectiveness of therapy on human leukemia.

Original language	English (US)
Pages (from-to)	481-484
Number of pages	4
Journal	Cancer
Volume	19
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(196604)19:4<481::AID-CNCR2820190404>3.0.CO;2-P
State	Published - Apr 1966

ASJC Scopus subject areas

Oncology
Cancer Research

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year = "1966",

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AU - Zelen, Marvin

AU - Freireich, Emil J.

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N2 - Data from studies of the duration of unmaintained remissions in human acute leukemia have been analyzed according to a murine L1210 leukemia model system. The pattern of recurrence follows an exponential distribution. The slope of recurrence (λ) was more shallow and the guarantee time (G) was longer for the intensive combination treatments (VAMP and BIKE) than for single drug treatment (vincristine and prednisone). The presented model provides the clinician with another potential tool for the analysis of the effectiveness of therapy on human leukemia.

AB - Data from studies of the duration of unmaintained remissions in human acute leukemia have been analyzed according to a murine L1210 leukemia model system. The pattern of recurrence follows an exponential distribution. The slope of recurrence (λ) was more shallow and the guarantee time (G) was longer for the intensive combination treatments (VAMP and BIKE) than for single drug treatment (vincristine and prednisone). The presented model provides the clinician with another potential tool for the analysis of the effectiveness of therapy on human leukemia.

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Evaluation of human acute leukemia data using a murine leukemia model system

Abstract

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