Evaluation of liver parenchyma stiffness in patients with liver tumours: optimal strategy for shear wave elastography

Wei Zheng, Zhong guo Zhou, Chong hei Wong, Xiao qing Pei, Shu lian Zhuang, Qing Li, Min-Shan Chen, An-Hua Li, Fu-Jun Zhang

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the methodology of non-invasive test for evaluation of liver stiffness (LS) with tumours using two-dimensional (2D) shear wave elastography (SWE). Methods: One hundred and twenty-seven patients with liver tumours underwent 2D-SWE before surgery to measure liver and spleen stiffness (SS). Two-dimensional SWE values were obtained in the liver at 0–1 cm, 1–2 cm and >2 cm from the tumour edge (PLS-1, PLS-2 and RLS, respectively). The influence of tumour-associated factors was evaluated. The area under the receiver operating characteristic curve (AUC) for each value was analysed to diagnose cirrhosis. Results: PLS-1 was higher than PLS-2, which was even higher than RLS (p < 0.001). The AUCs of PLS-1, PLS-2, RLS and SS for diagnosing cirrhosis were 0.760, 0.833, 0.940 and 0.676, with the specificity of 75.7%, 67.6%, 90.3% and 77.4%, respectively. Tumour sizes, locations or types showed no apparent influence on 2D-SWE values except for RLS, which was higher in patients with primary hepatic carcinomas (p < 0.05). Conclusions: LS with tumours is best measured at >2 cm away from the tumour edge. SS measurement could be used as an alternative to LS measurement in the event of no available liver for detection. Key Points: • Tumour-associated factors impact background liver stiffness assessment. • Background liver stiffness is best measured at >2 cm from tumour edge. • Spleen stiffness can be an alternative to assess background liver stiffness.

Original languageEnglish (US)
Pages (from-to)1479-1488
Number of pages10
JournalEuropean Radiology
Volume29
Issue number3
DOIs
StatePublished - Mar 2 2019

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Elasticity Imaging Techniques
Liver
Neoplasms
Spleen
ROC Curve
Area Under Curve
Fibrosis

Keywords

  • Elasticity imaging techniques
  • Liver cirrhosis
  • Liver neoplasms
  • Spleen
  • Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Evaluation of liver parenchyma stiffness in patients with liver tumours : optimal strategy for shear wave elastography. / Zheng, Wei; Zhou, Zhong guo; Wong, Chong hei; Pei, Xiao qing; Zhuang, Shu lian; Li, Qing; Chen, Min-Shan; Li, An-Hua; Zhang, Fu-Jun.

In: European Radiology, Vol. 29, No. 3, 02.03.2019, p. 1479-1488.

Research output: Contribution to journalArticle

Zheng, Wei ; Zhou, Zhong guo ; Wong, Chong hei ; Pei, Xiao qing ; Zhuang, Shu lian ; Li, Qing ; Chen, Min-Shan ; Li, An-Hua ; Zhang, Fu-Jun. / Evaluation of liver parenchyma stiffness in patients with liver tumours : optimal strategy for shear wave elastography. In: European Radiology. 2019 ; Vol. 29, No. 3. pp. 1479-1488.
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title = "Evaluation of liver parenchyma stiffness in patients with liver tumours: optimal strategy for shear wave elastography",
abstract = "Objectives: To determine the methodology of non-invasive test for evaluation of liver stiffness (LS) with tumours using two-dimensional (2D) shear wave elastography (SWE). Methods: One hundred and twenty-seven patients with liver tumours underwent 2D-SWE before surgery to measure liver and spleen stiffness (SS). Two-dimensional SWE values were obtained in the liver at 0–1 cm, 1–2 cm and >2 cm from the tumour edge (PLS-1, PLS-2 and RLS, respectively). The influence of tumour-associated factors was evaluated. The area under the receiver operating characteristic curve (AUC) for each value was analysed to diagnose cirrhosis. Results: PLS-1 was higher than PLS-2, which was even higher than RLS (p < 0.001). The AUCs of PLS-1, PLS-2, RLS and SS for diagnosing cirrhosis were 0.760, 0.833, 0.940 and 0.676, with the specificity of 75.7{\%}, 67.6{\%}, 90.3{\%} and 77.4{\%}, respectively. Tumour sizes, locations or types showed no apparent influence on 2D-SWE values except for RLS, which was higher in patients with primary hepatic carcinomas (p < 0.05). Conclusions: LS with tumours is best measured at >2 cm away from the tumour edge. SS measurement could be used as an alternative to LS measurement in the event of no available liver for detection. Key Points: • Tumour-associated factors impact background liver stiffness assessment. • Background liver stiffness is best measured at >2 cm from tumour edge. • Spleen stiffness can be an alternative to assess background liver stiffness.",
keywords = "Elasticity imaging techniques, Liver cirrhosis, Liver neoplasms, Spleen, Ultrasonography",
author = "Wei Zheng and Zhou, {Zhong guo} and Wong, {Chong hei} and Pei, {Xiao qing} and Zhuang, {Shu lian} and Qing Li and Min-Shan Chen and An-Hua Li and Fu-Jun Zhang",
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T1 - Evaluation of liver parenchyma stiffness in patients with liver tumours

T2 - optimal strategy for shear wave elastography

AU - Zheng, Wei

AU - Zhou, Zhong guo

AU - Wong, Chong hei

AU - Pei, Xiao qing

AU - Zhuang, Shu lian

AU - Li, Qing

AU - Chen, Min-Shan

AU - Li, An-Hua

AU - Zhang, Fu-Jun

PY - 2019/3/2

Y1 - 2019/3/2

N2 - Objectives: To determine the methodology of non-invasive test for evaluation of liver stiffness (LS) with tumours using two-dimensional (2D) shear wave elastography (SWE). Methods: One hundred and twenty-seven patients with liver tumours underwent 2D-SWE before surgery to measure liver and spleen stiffness (SS). Two-dimensional SWE values were obtained in the liver at 0–1 cm, 1–2 cm and >2 cm from the tumour edge (PLS-1, PLS-2 and RLS, respectively). The influence of tumour-associated factors was evaluated. The area under the receiver operating characteristic curve (AUC) for each value was analysed to diagnose cirrhosis. Results: PLS-1 was higher than PLS-2, which was even higher than RLS (p < 0.001). The AUCs of PLS-1, PLS-2, RLS and SS for diagnosing cirrhosis were 0.760, 0.833, 0.940 and 0.676, with the specificity of 75.7%, 67.6%, 90.3% and 77.4%, respectively. Tumour sizes, locations or types showed no apparent influence on 2D-SWE values except for RLS, which was higher in patients with primary hepatic carcinomas (p < 0.05). Conclusions: LS with tumours is best measured at >2 cm away from the tumour edge. SS measurement could be used as an alternative to LS measurement in the event of no available liver for detection. Key Points: • Tumour-associated factors impact background liver stiffness assessment. • Background liver stiffness is best measured at >2 cm from tumour edge. • Spleen stiffness can be an alternative to assess background liver stiffness.

AB - Objectives: To determine the methodology of non-invasive test for evaluation of liver stiffness (LS) with tumours using two-dimensional (2D) shear wave elastography (SWE). Methods: One hundred and twenty-seven patients with liver tumours underwent 2D-SWE before surgery to measure liver and spleen stiffness (SS). Two-dimensional SWE values were obtained in the liver at 0–1 cm, 1–2 cm and >2 cm from the tumour edge (PLS-1, PLS-2 and RLS, respectively). The influence of tumour-associated factors was evaluated. The area under the receiver operating characteristic curve (AUC) for each value was analysed to diagnose cirrhosis. Results: PLS-1 was higher than PLS-2, which was even higher than RLS (p < 0.001). The AUCs of PLS-1, PLS-2, RLS and SS for diagnosing cirrhosis were 0.760, 0.833, 0.940 and 0.676, with the specificity of 75.7%, 67.6%, 90.3% and 77.4%, respectively. Tumour sizes, locations or types showed no apparent influence on 2D-SWE values except for RLS, which was higher in patients with primary hepatic carcinomas (p < 0.05). Conclusions: LS with tumours is best measured at >2 cm away from the tumour edge. SS measurement could be used as an alternative to LS measurement in the event of no available liver for detection. Key Points: • Tumour-associated factors impact background liver stiffness assessment. • Background liver stiffness is best measured at >2 cm from tumour edge. • Spleen stiffness can be an alternative to assess background liver stiffness.

KW - Elasticity imaging techniques

KW - Liver cirrhosis

KW - Liver neoplasms

KW - Spleen

KW - Ultrasonography

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