Evaluation of point plaster therapy with ginger powder in preventing nausea and vomiting occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer

Hai Yan Lu, Yang Yang, Zhi Qiang Meng, Lei Hua Chen

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Objective: To evaluate the point plaster therapy with ginger powder combined with ondansetron hydrochloride in preventing nausea and vomiting usually occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer, and to compared its effectiveness with that by using ondansetron hydrochloride only. Method: Sixty-two patients with primary or metastatic liver cancer, who were scheduled to receive platinum-based interventional chemotherapy, were randomly and equally divided into two groups with 31 cases in each group. The patients in the study group (n = 31) were given point plaster therapy, i.e. externally applying ginger powder (20 g) to the point of Shenque, for four days together with arterial infusion of ondansetron hydrochloride (8 mg) during interventional procedure, while the patients in the control group (n = 31) were given point plaster therapy with placebo (potato powder) together with arterial infusion of ondansetron hydrochloride (8 mg) during interventional procedure. The questionnaire of INVR (index form for evaluating nausea and vomiting) was used to assess the effectiveness, and the results were compared between two groups. Results: The incidence of nausea and vomiting in study group was significantly lower than that in control group at all observed points of time during the period of 0-72 hours after the treatment (P < 0.05). The occurrence of retching in study group was significantly lower than that in control group (P < 0.05) for the whole observed period except for the period from 49 to 60 hours after chemotherapy (P > 0.05). After the treatment the scores of nausea, vomiting and retching in the study group were 0.45, 0.25 and 0.19 respectively, while these in the control group were 2.77, 0.87 and 0.97 respectively, the differences between two groups were statistically significant (P < 0.05). Conclusion: The external application of ginger powder to points of Shenque can markedly decrease the incidence and severity of nausea and vomiting after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer.

    Original languageEnglish (US)
    Pages (from-to)664-668
    Number of pages5
    JournalJournal of Interventional Radiology
    Volume19
    Issue number8
    StatePublished - Aug 2010

    Keywords

    • Ginger
    • Intervention
    • Liver cancer
    • Nausea
    • Platinum-based chemotherapy
    • Retching
    • Vomiting

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Fingerprint

    Dive into the research topics of 'Evaluation of point plaster therapy with ginger powder in preventing nausea and vomiting occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer'. Together they form a unique fingerprint.

    Cite this