Evaluation of the biodistribution of serinolamide-derivatized c60 fullerene

Nicholas G. Zaibaq; Alyssa C. Pollard; Michael J. Collins; Federica Pisaneschi; Mark D. Pagel; Lon J. Wilson

doi:10.3390/nano10010143

Evaluation of the biodistribution of serinolamide-derivatized c₆₀ fullerene

Nicholas G. Zaibaq, Alyssa C. Pollard, Michael J. Collins, Federica Pisaneschi, Mark D. Pagel, Lon J. Wilson

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C₆₀ derivative with a metal chelating agent (NOTA) covalently bound to the C₆₀ cage and radiolabeled with copper-64 (t_1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C₆₀ conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C₆₀-based biomedical platforms.

Original language	English (US)
Article number	143
Journal	Nanomaterials
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/nano10010143
State	Published - Jan 2020

Keywords

Biodistribution
Fullerene
PET
Pharmacokinetics
Serinolamide

ASJC Scopus subject areas

General Chemical Engineering
General Materials Science

MD Anderson CCSG core facilities

Small Animal Imaging Facility
Research Animal Support Facility

Access to Document

10.3390/nano10010143

Cite this

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title = "Evaluation of the biodistribution of serinolamide-derivatized c60 fullerene",

abstract = "Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms.",

keywords = "Biodistribution, Fullerene, PET, Pharmacokinetics, Serinolamide",

author = "Zaibaq, {Nicholas G.} and Pollard, {Alyssa C.} and Collins, {Michael J.} and Federica Pisaneschi and Pagel, {Mark D.} and Wilson, {Lon J.}",

note = "Funding Information: Funding: This work was supported by the NSF Graduate Research Fellowship Program (1450681) to N.G.Z. and the Welch Foundation (Grant C-0627) to L.J.W. A.C.P was supported by a fellowship from NIH/NCI T32 grant T32CA196561. This work was also supported by the NIH/NCI under award number P30CA016672 and used the Small Animal Imaging Facility at the MD Anderson Cancer Center. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Pisaneschi, Federica

AU - Pagel, Mark D.

AU - Wilson, Lon J.

N1 - Funding Information: Funding: This work was supported by the NSF Graduate Research Fellowship Program (1450681) to N.G.Z. and the Welch Foundation (Grant C-0627) to L.J.W. A.C.P was supported by a fellowship from NIH/NCI T32 grant T32CA196561. This work was also supported by the NIH/NCI under award number P30CA016672 and used the Small Animal Imaging Facility at the MD Anderson Cancer Center. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms.

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