TY - JOUR
T1 - Evidence-based mini-review
T2 - the role of alkylating agents in the initial treatment of chronic lymphocytic leukemia patients with the 11q deletion.
AU - Ding, Wei
AU - Ferrajoli, Alessandra
PY - 2010
Y1 - 2010
N2 - A 55-year-old man presented with fever, night sweats, and weight loss of about 20 lbs. in the prior 6 months. Physical examination revealed multiple cervical, axillary, and inguinal lymphadenopathy. The spleen was enlarged. A complete blood count revealed leukocytosis with absolute lymphocytosis: 30,000/μL. Peripheral blood-flow cytometric analysis showed a clonal lymphocyte population with immunophenotypes positive for CD5, CD20(dim), and monotypic kappa light chain. Fluorescence in situ hybridization (FISH) analysis revealed del(11q22.3), but negative for t(11:14). What should be used to treat his chronic lymphocytic leukemia (CLL) disease?
AB - A 55-year-old man presented with fever, night sweats, and weight loss of about 20 lbs. in the prior 6 months. Physical examination revealed multiple cervical, axillary, and inguinal lymphadenopathy. The spleen was enlarged. A complete blood count revealed leukocytosis with absolute lymphocytosis: 30,000/μL. Peripheral blood-flow cytometric analysis showed a clonal lymphocyte population with immunophenotypes positive for CD5, CD20(dim), and monotypic kappa light chain. Fluorescence in situ hybridization (FISH) analysis revealed del(11q22.3), but negative for t(11:14). What should be used to treat his chronic lymphocytic leukemia (CLL) disease?
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UR - http://www.scopus.com/inward/citedby.url?scp=79955007785&partnerID=8YFLogxK
U2 - 10.1182/asheducation-2010.1.90
DO - 10.1182/asheducation-2010.1.90
M3 - Review article
C2 - 21239776
AN - SCOPUS:79955007785
SN - 1520-4391
VL - 2010
SP - 90
EP - 92
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -