TY - JOUR
T1 - Ewing sarcoma with extensive neural differentiation
T2 - A clinicopathologic, immunohistochemical, and molecular analysis of three cases
AU - Weissferdt, Annikka
AU - Kalhor, Neda
AU - Moran, Cesar A.
N1 - Publisher Copyright:
© American Society for Clinical Pathology.
PY - 2015/5
Y1 - 2015/5
N2 - Objectives: Three patients with Ewing sarcomas showing extensive neural differentiation are presented. Methods: The patients were two women and one man between the ages of 15 and 35 years. Anatomically, one tumor was in the lung, one in the testis, and one in the cervix uteri. The symptoms were determined by the location of the neoplasm and included respiratory symptoms, testicular pain, and pelvic manifestations, respectively. Complete surgical resection of the tumors was performed. Results: Histologically, all neoplasms showed similar characteristics-namely, a neoplastic cellular proliferation arranged in sheets and composed of small blue cells with round to oval nuclei and inconspicuous nucleoli typical for Ewing sarcoma. In addition, in two cases, there were areas characterized by the presence of neuropil, ganglion cells, and small cells most compatible with ganglioneuroblastoma, while in one tumor, the neural component was characterized by the presence of small cells with prominent perivascular pseudorosettes more closely resembling ependymoma. Immunohistochemical studies in all cases and molecular analysis in two tumors were in keeping with a diagnosis of Ewing sarcoma. Conclusions: The recognition of such histologic variants is important in the diagnostic assessment of these tumors to avoid misinterpretation, especially in small biopsy specimens.
AB - Objectives: Three patients with Ewing sarcomas showing extensive neural differentiation are presented. Methods: The patients were two women and one man between the ages of 15 and 35 years. Anatomically, one tumor was in the lung, one in the testis, and one in the cervix uteri. The symptoms were determined by the location of the neoplasm and included respiratory symptoms, testicular pain, and pelvic manifestations, respectively. Complete surgical resection of the tumors was performed. Results: Histologically, all neoplasms showed similar characteristics-namely, a neoplastic cellular proliferation arranged in sheets and composed of small blue cells with round to oval nuclei and inconspicuous nucleoli typical for Ewing sarcoma. In addition, in two cases, there were areas characterized by the presence of neuropil, ganglion cells, and small cells most compatible with ganglioneuroblastoma, while in one tumor, the neural component was characterized by the presence of small cells with prominent perivascular pseudorosettes more closely resembling ependymoma. Immunohistochemical studies in all cases and molecular analysis in two tumors were in keeping with a diagnosis of Ewing sarcoma. Conclusions: The recognition of such histologic variants is important in the diagnostic assessment of these tumors to avoid misinterpretation, especially in small biopsy specimens.
KW - Ewing sarcoma
KW - Neural
KW - Sarcoma
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U2 - 10.1309/AJCPFHFX07JFCRGU
DO - 10.1309/AJCPFHFX07JFCRGU
M3 - Article
C2 - 25873499
AN - SCOPUS:84937131632
SN - 0002-9173
VL - 143
SP - 659
EP - 664
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -