Ex vivo expansion of umbilical cord blood for transplantation

S. S. Tung, S. Parmar, S. N. Robinson, M. De Lima, E. J. Shpall

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Umbilical cord blood (UCB) has become an important source of hematopoietic stem cell transplant (HSCT) for hematologic malignancies in adults. Its ready availability, allowance of higher HLA disparity and lower incidence of graft-versus-host disease (GVHD) makes it a very attractive source especially for minority populations. The major limitation to a wider use of this source of HSCT is the relative low number of progenitor cells in the graft. For this reason, adult UCB transplants are usually associated with delayed engraftment and increased rates of infectious complications. CB ex vivo expansion holds the promise of delivering higher cell doses and improved outcomes. Here we discuss different methods of expansion, their shortcomings and future directions.

Original languageEnglish (US)
Pages (from-to)245-257
Number of pages13
JournalBest Practice and Research: Clinical Haematology
Volume23
Issue number2
DOIs
StatePublished - Jun 2010

Keywords

  • ex vivo expansion
  • immune reconstitution
  • umbilical cord blood transplant

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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