@inbook{889c8c96d768440dbe7b14423a69723e,
title = "Ex Vivo Pharmacological Profiling in Chronic Lymphocytic Leukemia Cells",
abstract = "In vitro drug combination studies are commonly used for CLL primary lymphocytes. An advancement in this method is to perform ex vivo drug testing where the first agent is administered to patients and second drug is tested in these patients{\textquoteright} cells in vitro. These assays have been effective in identifying novel agents that work additively or synergistically. In this chapter, we provide a step-by-step protocol for ex vivo drug testing that can be used for combination strategies.",
keywords = "Annexin V-FITC/PI staining, Apoptosis, CLL, Combination therapy, Ex vivo drug testing, Flow cytometry, Targeted therapeutics",
author = "Burcu Aslan and Ayres, {Mary L.} and Varsha Gandhi",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2019",
doi = "10.1007/978-1-4939-8876-1_2",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "19--25",
booktitle = "Methods in Molecular Biology",
}