Exchange-coupled magnetic nanoparticles for efficient heat induction

Jae Hyun Lee, Jung Tak Jang, Jin Sil Choi, Seung Ho Moon, Seung Hyun Noh, Ji Wook Kim, Jin Gyu Kim, Il Sun Kim, Kook In Park, Jinwoo Cheon

    Research output: Contribution to journalArticle

    791 Scopus citations

    Abstract

    The conversion of electromagnetic energy into heat by nanoparticles has the potential to be a powerful, non-invasive technique for biotechnology applications such as drug release, disease treatment and remote control of single cell functions, but poor conversion efficiencies have hindered practical applications so far. In this Letter, we demonstrate a significant increase in the efficiency of magnetic thermal induction by nanoparticles. We take advantage of the exchange coupling between a magnetically hard core and magnetically soft shell to tune the magnetic properties of the nanoparticle and maximize the specific loss power, which is a gauge of the conversion efficiency. The optimized core-shell magnetic nanoparticles have specific loss power values that are an order of magnitude larger than conventional iron-oxide nanoparticles. We also perform an antitumour study in mice, and find that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.

    Original languageEnglish (US)
    Pages (from-to)418-422
    Number of pages5
    JournalNature Nanotechnology
    Volume6
    Issue number7
    DOIs
    StatePublished - Jul 2011

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    ASJC Scopus subject areas

    • Bioengineering
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering
    • Materials Science(all)
    • Condensed Matter Physics
    • Electrical and Electronic Engineering

    Cite this

    Lee, J. H., Jang, J. T., Choi, J. S., Moon, S. H., Noh, S. H., Kim, J. W., Kim, J. G., Kim, I. S., Park, K. I., & Cheon, J. (2011). Exchange-coupled magnetic nanoparticles for efficient heat induction. Nature Nanotechnology, 6(7), 418-422. https://doi.org/10.1038/nnano.2011.95