Abstract
Many screening methods have been developed to identify novel inhibitors for drug design. Although both virtual and experimental high throughput approaches have successfully discovered new lead compounds [1-8], it has become clear that screening hit lists are plagued by problematic molecules. Often, these compounds display perplexing behaviors, such as a flat structure-activity relationship [2], time-dependent activity, and steep inhibition curves [9]. Because of these undesirable properties, many screening hits end up as developmental dead ends, often after considerable time and resources have been devoted to them.
Original language | English (US) |
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Title of host publication | Virtual Screening in Drug Discovery |
Publisher | CRC Press |
Pages | 107-124 |
Number of pages | 18 |
ISBN (Electronic) | 9781420028775 |
ISBN (Print) | 9780824754792 |
State | Published - Jan 1 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine
- General Chemistry