TY - JOUR
T1 - Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy
T2 - an international and multidisciplinary consensus statement
AU - Di Nardo, Matteo
AU - Ahmad, Ali H.
AU - Merli, Pietro
AU - Zinter, Matthew S.
AU - Lehman, Leslie E.
AU - Rowan, Courtney M.
AU - Steiner, Marie E.
AU - Hingorani, Sangeeta
AU - Angelo, Joseph R.
AU - Abdel-Azim, Hisham
AU - Khazal, Sajad J.
AU - Shoberu, Basirat
AU - McArthur, Jennifer
AU - Bajwa, Rajinder
AU - Ghafoor, Saad
AU - Shah, Samir H.
AU - Sandhu, Hitesh
AU - Moody, Karen
AU - Brown, Brandon D.
AU - Mireles, Maria E.
AU - Steppan, Diana
AU - Olson, Taylor
AU - Raman, Lakshmi
AU - Bridges, Brian
AU - Duncan, Christine N.
AU - Choi, Sung Won
AU - Swinford, Rita
AU - Paden, Matt
AU - Fortenberry, James D.
AU - Peek, Giles
AU - Tissieres, Pierre
AU - De Luca, Daniele
AU - Locatelli, Franco
AU - Corbacioglu, Selim
AU - Kneyber, Martin
AU - Franceschini, Alessio
AU - Nadel, Simon
AU - Kumpf, Matthias
AU - Loreti, Alessandra
AU - Wösten-Van Asperen, Roelie
AU - Gawronski, Orsola
AU - Brierley, Joe
AU - MacLaren, Graeme
AU - Mahadeo, Kris M.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/2
Y1 - 2022/2
N2 - Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements in HCT and immune effector cell therapies have changed expectations around reversibility of organ dysfunction and survival for affected patients. Herein, members of the Extracorporeal Life Support Organization (ELSO), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (HCT and cancer immunotherapy subgroup), the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT), the supportive care committee of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC), and the Pediatric Intensive Care Oncology Kids in Europe Research (POKER) group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) provide consensus recommendations on the use of ECMO in children receiving HCT and immune effector cell therapy. These are the first international, multidisciplinary consensus-based recommendations on the use of ECMO in this patient population. This Review provides a clinical decision support tool for paediatric haematologists, oncologists, and critical care physicians during the difficult decision-making process of ECMO candidacy and management. These recommendations can represent a base for future research studies focused on ECMO selection criteria and bedside management.
AB - Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements in HCT and immune effector cell therapies have changed expectations around reversibility of organ dysfunction and survival for affected patients. Herein, members of the Extracorporeal Life Support Organization (ELSO), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (HCT and cancer immunotherapy subgroup), the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT), the supportive care committee of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC), and the Pediatric Intensive Care Oncology Kids in Europe Research (POKER) group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) provide consensus recommendations on the use of ECMO in children receiving HCT and immune effector cell therapy. These are the first international, multidisciplinary consensus-based recommendations on the use of ECMO in this patient population. This Review provides a clinical decision support tool for paediatric haematologists, oncologists, and critical care physicians during the difficult decision-making process of ECMO candidacy and management. These recommendations can represent a base for future research studies focused on ECMO selection criteria and bedside management.
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U2 - 10.1016/S2352-4642(21)00336-9
DO - 10.1016/S2352-4642(21)00336-9
M3 - Review article
C2 - 34895512
AN - SCOPUS:85122921646
SN - 2352-4642
VL - 6
SP - 116
EP - 128
JO - The Lancet Child and Adolescent Health
JF - The Lancet Child and Adolescent Health
IS - 2
ER -