Fabrication and Testing of a Gold Nanoparticle-loaded Tissue-mimicking Phantom for Validation of Gold L-shell X-ray Fluorescence Imaging Results

Sandun Jayarathna, Md Foiez Ahmed, Sang Hyun Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We previously reported the development of direct X-ray fluorescence (XRF) imaging system for quantitative imaging of gold nanoparticles (GNPs) on a benchtop setting. This system is implemented with an ordinary polychromatic X-ray source and, by detecting gold L-shell XRF photons, is capable of detecting/imaging trace amounts of gold nanoparticles (GNPs), on the order of parts-per-million (ppm), under the calibration conditions. For routine XRF imaging of biological samples (e.g., explanted tumors) containing ppm-level GNPs, this system needs to be tested further under more realistic imaging conditions. Thus, we developed a GNP-loaded tissue-mimicking phantom and performed a phantom imaging study using our benchtop XRF imaging system. For the tissue-mimicking phantom construction, the GNP-filled capillary tubes with known GNP concentrations were placed in an 'E' shaped pattern and sandwiched between three layers of cheese. The results (i.e., XRF map) from the scanning of this phantom showed that the 'E' shape of the phantom was well visible in the XRF map and all three arms and the stem of 'E' were spatially resolved within ∼2 mm. The measured GNP concentrations were in good agreement with the known GNP concentrations.

Original languageEnglish (US)
Title of host publication2019 IEEE 13th International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
PublisherIEEE Computer Society
Pages22-25
Number of pages4
ISBN (Electronic)9781728166483
DOIs
StatePublished - Nov 2019
Event13th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019 - Gwangju, Korea, Republic of
Duration: Nov 21 2019Nov 24 2019

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Volume2020-November
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Conference13th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
CountryKorea, Republic of
CityGwangju
Period11/21/1911/24/19

Keywords

  • Gold L-shell X-ray Fluorescence
  • Gold Nanoparticles
  • Silicon Drift Detector
  • X-ray Fluorescence Imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Microbiology (medical)

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