Familial risks in testicular cancer as aetiological clues

Kari Hemminki, Bowang Chen, T. Schettler, S. J. Assinder

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We used the nationwide Swedish Family-Cancer Database to analyse the risk for testicular cancer in offspring through parental and sibling probands. Among 0 to 70-year-old offspring, 4586 patients had testicular cancer. Standardized incidence ratios for familial risk were 3.8-fold when a father and 7.6-fold when a brother had testicular cancer. Testicular cancer was associated with leukaemia, distal colon and kidney cancer, melanoma, connective tissue tumours and lung cancer in families. Non-seminoma was associated with maternal lung cancer but the risk was highest for the late-onset cases, providing no support to the theory of the in utero effect of maternal smoking on the son's risk of testicular cancer. However, the theory cannot be excluded but should be taken up for study when further data are available on maternal smoking. The high familial risk may be the product of shared childhood environment and heritable causes.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalInternational Journal of Andrology
Volume29
Issue number1
DOIs
StatePublished - Feb 1 2006

Fingerprint

Testicular Neoplasms
Mothers
Siblings
Lung Neoplasms
Smoking
Kidney Neoplasms
Nuclear Family
Fathers
Connective Tissue
Colonic Neoplasms
Melanoma
Neoplasms
Leukemia
Odds Ratio
Databases
Incidence

Keywords

  • Familial risk
  • Maternal smoking
  • Non-seminoma
  • Seminoma
  • Testicular cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Urology

Cite this

Familial risks in testicular cancer as aetiological clues. / Hemminki, Kari; Chen, Bowang; Schettler, T.; Assinder, S. J.

In: International Journal of Andrology, Vol. 29, No. 1, 01.02.2006, p. 205-210.

Research output: Contribution to journalArticle

Hemminki, Kari ; Chen, Bowang ; Schettler, T. ; Assinder, S. J. / Familial risks in testicular cancer as aetiological clues. In: International Journal of Andrology. 2006 ; Vol. 29, No. 1. pp. 205-210.
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