Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Sara Lovisa; Raghu Kalluri

doi:10.1016/j.molmed.2018.03.003

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Sara Lovisa, Raghu Kalluri

Cancer Biology

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.

Original language	English (US)
Pages (from-to)	432-434
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.molmed.2018.03.003
State	Published - May 2018

Keywords

EndMT
endothelial cells
endothelial-to-mesenchymal transition
fatty acid oxidation
metabolism

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2018.03.003

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title = "Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition",

abstract = "The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.",

keywords = "EndMT, endothelial cells, endothelial-to-mesenchymal transition, fatty acid oxidation, metabolism",

author = "Sara Lovisa and Raghu Kalluri",

note = "Funding Information: Research work in the laboratory of R.K. is supported by the Cancer Prevention and Research Institute of Texas and the M.D. Anderson Cancer Center. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

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AU - Lovisa, Sara

AU - Kalluri, Raghu

N1 - Funding Information: Research work in the laboratory of R.K. is supported by the Cancer Prevention and Research Institute of Texas and the M.D. Anderson Cancer Center. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/5

Y1 - 2018/5

N2 - The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.

AB - The molecular mechanisms underpinning the process of endothelial-to-mesenchymal transition (EndMT) are mostly unknown. Recently Xiong and colleagues explored for the first time the metabolic changes associated with the activation of the mesenchymal program in endothelial cells, and found that reprogramming of fatty acid oxidation pivotally regulates EndMT.

KW - EndMT

KW - endothelial cells

KW - endothelial-to-mesenchymal transition

KW - fatty acid oxidation

KW - metabolism

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JO - Trends in Molecular Medicine

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IS - 5

ER -

Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition

Abstract

Keywords

ASJC Scopus subject areas

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