Feasibility of X-ray Fluorescence Computed Tomography (XFCT) Imaging of Human Lung Tumors loaded with Gold Nanoparticles: A Monte Carlo Study

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

We present a novel Monte Carlo model of x-ray fluorescence (XRF) computed tomography (XFCT) imaging of human lung tumors loaded with gold nanoparticles (GNPs). In this model, the lung phantom derived from CT images was excited using a fan/cone beam of x-rays and the XRF/Scatter photons were detected using linear array detectors coupled with parallel-hole collimators. Whereas 1 wt. % GNP regions located at ~4-5 centimeter depths within the phantom could be detected reliably under the current conditions, it became challenging to detect such GNP regions present at deeper depths. Nevertheless, this study opened up the possibility to apply XFCT techniques for human lung cancer detection in conjunction with GNPs.

Original languageEnglish (US)
Title of host publicationProceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
PublisherIEEE Computer Society
Pages250-254
Number of pages5
ISBN (Electronic)9781538675786
DOIs
StatePublished - Jul 2 2018
Event12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018 - Waikiki Beach, United States
Duration: Dec 2 2018Dec 5 2018

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Volume2018-December
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Conference12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018
Country/TerritoryUnited States
CityWaikiki Beach
Period12/2/1812/5/18

Keywords

  • Gold Nanoparticles
  • Lung cancer
  • Monte Carlo
  • X-ray Fluorescence Computed Tomography

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Microbiology (medical)

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