Ferroptosis, radiotherapy, and combination therapeutic strategies

Guang Lei, Chao Mao, Yuelong Yan, Li Zhuang, Boyi Gan

Research output: Contribution to journalReview articlepeer-review

154 Scopus citations

Abstract

Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.

Original languageEnglish (US)
Pages (from-to)836-857
Number of pages22
JournalProtein and Cell
Volume12
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • GPX4
  • SLC7A11
  • combination therapy
  • ferroptosis
  • immunotherapy
  • lipid peroxidation
  • radiosensitization
  • radiotherapy

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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