Abstract
Male sexual differentiation is a complex process requiring the hormone-producing function of somatic cells in the gonad, including Sertoli cells and fetal Leydig cells (FLCs). FLCs are essential for virilization of the male embryo, but despite their crucial function, relatively little is known about their origins or development. Adult Leydig cells (ALCs), which arise at puberty, have been studied extensively and much of what has been learned about this cell population has been extrapolated to FLCs. This approach is problematic in that prevailing dogma in the field asserts that these 2 populations are distinct in origin. As such, it is imprudent to assume that FLCs arise and develop in a similar manner to ALCs. This review provides a critical assessment of studies performed on FLC populations, rather than those extrapolated from ALC studies to assemble a model for FLC origins and development. Furthermore, we underscore the need for conclusive identification of the source population of fetal Leydig cells.
Original language | English (US) |
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Pages (from-to) | 1-15 |
Number of pages | 15 |
Journal | Sexual Development |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2009 |
Keywords
- Adrenogonadal primordium
- Adult Leydig cells
- Fetal Leydig cells
- Leydig stem cells
- Multipotent progenitor
- SF-1
- Testis development
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Embryology
- Developmental Biology