Fibroblast growth factor signaling during early vertebrate development

Ralph T. Böttcher, Christof Niehrs

    Research output: Contribution to journalReview article

    396 Scopus citations


    Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.

    Original languageEnglish (US)
    Pages (from-to)63-77
    Number of pages15
    JournalEndocrine reviews
    Issue number1
    StatePublished - Feb 1 2005

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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