Fibroblast growth factors signaling in bone metastasis

Estefania Labanca; Elba S. Vazquez; Paul G. Corn; Justin M. Roberts; Fen Wang; Christopher J. Logothetis; Nora M. Navone

doi:10.1530/ERC-19-0472

Fibroblast growth factors signaling in bone metastasis

Estefania Labanca, Elba S. Vazquez, Paul G. Corn, Justin M. Roberts, Fen Wang, Christopher J. Logothetis, Nora M. Navone

Genitourinary Medical Oncology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.

Original language	English (US)
Pages (from-to)	R255-R265
Journal	Endocrine-related cancer
Volume	127
Issue number	7
DOIs	https://doi.org/10.1530/ERC-19-0472
State	Published - Jul 2020

Keywords

Bone metastasis
Fibroblast growth factor receptors
Fibroblast growth factors
Prostate cancer

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Cancer Research

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10.1530/ERC-19-0472

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title = "Fibroblast growth factors signaling in bone metastasis",

abstract = "Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.",

keywords = "Bone metastasis, Fibroblast growth factor receptors, Fibroblast growth factors, Prostate cancer",

author = "Estefania Labanca and Vazquez, {Elba S.} and Corn, {Paul G.} and Roberts, {Justin M.} and Fen Wang and Logothetis, {Christopher J.} and Navone, {Nora M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The authors Published by Bioscientifica Ltd. Printed in Great Britain",

year = "2020",

month = jul,

doi = "10.1530/ERC-19-0472",

language = "English (US)",

volume = "127",

pages = "R255--R265",

journal = "Endocrine-related cancer",

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TY - JOUR

T1 - Fibroblast growth factors signaling in bone metastasis

AU - Labanca, Estefania

AU - Vazquez, Elba S.

AU - Corn, Paul G.

AU - Roberts, Justin M.

AU - Wang, Fen

AU - Logothetis, Christopher J.

AU - Navone, Nora M.

PY - 2020/7

Y1 - 2020/7

N2 - Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.

AB - Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some tumors and mounting evidence indicate that it mediates prostate cancer bone metastases. The FGF axis has an important role in bone biology and mediates cell-to-cell communication. Therefore, we discuss here basic concepts of bone biology, FGF signaling axis, and FGF axis function in adult bone, to integrate these concepts in our current understanding of the role of FGF axis in bone metastases.

KW - Bone metastasis

KW - Fibroblast growth factor receptors

KW - Fibroblast growth factors

KW - Prostate cancer

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DO - 10.1530/ERC-19-0472

M3 - Review article

C2 - 32369771

AN - SCOPUS:85086053060

SN - 1351-0088

VL - 127

SP - R255-R265

JO - Endocrine-related cancer

JF - Endocrine-related cancer

IS - 7

ER -

Fibroblast growth factors signaling in bone metastasis

Abstract

Keywords

ASJC Scopus subject areas

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