Finasteride use and acute pancreatitis in Taiwan

Shih Wei Lai, Hsueh Chou Lai, Cheng Li Lin, Kuan Fu Liao

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    The aim of this study was to examine whether there is an association between finasteride use and the risk of acute pancreatitis. This population-based case-control study used the database of the Taiwan National Health Insurance Program. There were 2,530 male subjects aged 40-84 years with a first-attack of acute pancreatitis during the period of 1998-2011 as the case group and 10,119 randomly selected subjects without acute pancreatitis as the control group. Both groups were matched by age and index year of diagnosing acute pancreatitis. Subjects who never had finasteride prescription were defined as "never use." Subjects who at least received 1 prescription for finasteride before the date of diagnosing acute pancreatitis were defined as "ever use." The association of acute pancreatitis with finasteride use was examined by the odds ratio (OR) and 95% confidence interval (CI) using the multivariable unconditional logistic regression model. The crude OR of acute pancreatitis was 1.78 (95%CI 1.33, 2.39) for subjects with ever use of finasteride, when compared with subjects with never use of finasteride. After adjusting for potential confounders, the adjusted OR of acute pancreatitis decreased to 1.25 (95%CI 0.90, 1.73) for subjects with ever use of finasteride, but no statistical significance was seen. No association can be detected between finasteride use and the risk of acute pancreatitis.

    Original languageEnglish (US)
    Pages (from-to)657-660
    Number of pages4
    JournalJournal of Clinical Pharmacology
    Volume55
    Issue number6
    DOIs
    StatePublished - Jun 1 2015

    Keywords

    • acute pancreatitis
    • alcoholism
    • biliary stone
    • diabetes mellitus
    • finasteride

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

    Fingerprint Dive into the research topics of 'Finasteride use and acute pancreatitis in Taiwan'. Together they form a unique fingerprint.

  • Cite this

    Lai, S. W., Lai, H. C., Lin, C. L., & Liao, K. F. (2015). Finasteride use and acute pancreatitis in Taiwan. Journal of Clinical Pharmacology, 55(6), 657-660. https://doi.org/10.1002/jcph.462