Flipping the oncogene switch: Illumination of tumor maintenance and regression

Lynda Chin, Ronald A. DePinho

Research output: Contribution to journalShort surveypeer-review

28 Scopus citations


The genetic construction of cancer-prone mice, combined with the capacity to control transgene expression in vivo, provides new opportunities to study the role of oncogenes in the maintenance of fully formed tumors. These inducible cancer models provide a means to dissect how specific oncogenic signals influence host-tumor symbiosis, to validate the importance of a given oncogenic lesion in established advanced tumors, and to predict the biological response and adaptations to therapies targeted to that cancer-causing genetic alteration. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalTrends in Genetics
Issue number4
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Genetics


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