Fluorescence spectroscopy and imaging for noninvasive diagnostics: Applications to early cancer detection in the lung

Mary Ann Mycek, Paul Urayama, Wei Zhong, Roger D. Sloboda, Konstantin H. Dragnev, Ethan Dmitrovsky

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

Tissue fluorescence spectroscopy and imaging are being investigated as potential methods for non-invasive detection of pre-neoplastic change in the lung and other organ systems. A substantial contribution to tissue fluorescence is known to arise from endogenous cellular fluorophores. Using steady-state and time-resolved fluorescence spectroscopy and imaging, we characterized the endogenous fluorescence properties of immortalized and carcinogen transformed human bronchial epithelial cells. Non-invasive sensing of endogenous molecular biomarkers associated with human bronchial pre-neoplasia will be discussed.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5141
DOIs
StatePublished - 2003
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Keywords

  • Fluorescence diagnostics
  • Fluorescence lifetime spectroscopy and imaging
  • Neoplasia detection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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