Focal fatty infiltration of the liver: Analysis of prevalence and CT findings in children and young adults

B. F. Kammen, P. Pacharn, R. F. Thoeni, Y. Lu, Aliya Qayyum, F. Coakly, C. A. Gooding, R. C. Brasch

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE. Focal fatty infiltration of the liver, a benign entity that can be confused with a malignant lesion, is well characterized in adults but not in children. The goal of this study was to determine by CT the prevalence and characteristics of focal fatty infiltration in children and young adults. MATERIALS AND METHODS. We retrospectively analyzed 305 consecutive contrast-enhanced abdominal CT examinations of 218 children and young adults with no known liver disease, performed during 2 years at our institution, to identify focal fatty infiltration of the liver. The imaging criterion for focal fatty infiltration of the liver on helical CT was a geometric or ovoid low-attenuation area adjacent to the falciform ligament, gallbladder fossa, or porta hepatis. If a patient's findings met the CT criterion for focal fatty infiltration of the liver, all previous abdominal CT and MR imaging examinations performed for that patient were reviewed to assess the evolution of focal fatty infiltration of the liver. RESULTS. Of 218 children and young adults, 20 (9.2%) met the CT criterion for focal fatty infiltration of the liver. In our population, focal fatty infiltration of the liver was identified only adjacent to the falciform ligament. The prevalence of focal fatty infiltration of the liver increased significantly with advancing age: 0% for ages 1 month-4 years; 7.3% for 5-9 years; 10.2% for 10-14 years, and 25.6% for 15-19 years (p < 0.0001). CONCLUSION. Focal fatty infiltration of the liver was identified in 9.2% of patients in our population, and occurrence of this lesion in children increases significantly with advancing age. However, focal fatty infiltration of the liver is uncommon in infants and young children and should be a diagnosis of exclusion.

Original languageEnglish (US)
Pages (from-to)1035-1039
Number of pages5
JournalAmerican Journal of Roentgenology
Volume177
Issue number5
StatePublished - 2001

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Fatty Liver
Young Adult
Ligaments
Spiral Computed Tomography
Gallbladder
Population
Liver Diseases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kammen, B. F., Pacharn, P., Thoeni, R. F., Lu, Y., Qayyum, A., Coakly, F., ... Brasch, R. C. (2001). Focal fatty infiltration of the liver: Analysis of prevalence and CT findings in children and young adults. American Journal of Roentgenology, 177(5), 1035-1039.

Focal fatty infiltration of the liver : Analysis of prevalence and CT findings in children and young adults. / Kammen, B. F.; Pacharn, P.; Thoeni, R. F.; Lu, Y.; Qayyum, Aliya; Coakly, F.; Gooding, C. A.; Brasch, R. C.

In: American Journal of Roentgenology, Vol. 177, No. 5, 2001, p. 1035-1039.

Research output: Contribution to journalArticle

Kammen, BF, Pacharn, P, Thoeni, RF, Lu, Y, Qayyum, A, Coakly, F, Gooding, CA & Brasch, RC 2001, 'Focal fatty infiltration of the liver: Analysis of prevalence and CT findings in children and young adults', American Journal of Roentgenology, vol. 177, no. 5, pp. 1035-1039.
Kammen, B. F. ; Pacharn, P. ; Thoeni, R. F. ; Lu, Y. ; Qayyum, Aliya ; Coakly, F. ; Gooding, C. A. ; Brasch, R. C. / Focal fatty infiltration of the liver : Analysis of prevalence and CT findings in children and young adults. In: American Journal of Roentgenology. 2001 ; Vol. 177, No. 5. pp. 1035-1039.
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abstract = "OBJECTIVE. Focal fatty infiltration of the liver, a benign entity that can be confused with a malignant lesion, is well characterized in adults but not in children. The goal of this study was to determine by CT the prevalence and characteristics of focal fatty infiltration in children and young adults. MATERIALS AND METHODS. We retrospectively analyzed 305 consecutive contrast-enhanced abdominal CT examinations of 218 children and young adults with no known liver disease, performed during 2 years at our institution, to identify focal fatty infiltration of the liver. The imaging criterion for focal fatty infiltration of the liver on helical CT was a geometric or ovoid low-attenuation area adjacent to the falciform ligament, gallbladder fossa, or porta hepatis. If a patient's findings met the CT criterion for focal fatty infiltration of the liver, all previous abdominal CT and MR imaging examinations performed for that patient were reviewed to assess the evolution of focal fatty infiltration of the liver. RESULTS. Of 218 children and young adults, 20 (9.2{\%}) met the CT criterion for focal fatty infiltration of the liver. In our population, focal fatty infiltration of the liver was identified only adjacent to the falciform ligament. The prevalence of focal fatty infiltration of the liver increased significantly with advancing age: 0{\%} for ages 1 month-4 years; 7.3{\%} for 5-9 years; 10.2{\%} for 10-14 years, and 25.6{\%} for 15-19 years (p < 0.0001). CONCLUSION. Focal fatty infiltration of the liver was identified in 9.2{\%} of patients in our population, and occurrence of this lesion in children increases significantly with advancing age. However, focal fatty infiltration of the liver is uncommon in infants and young children and should be a diagnosis of exclusion.",
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T1 - Focal fatty infiltration of the liver

T2 - Analysis of prevalence and CT findings in children and young adults

AU - Kammen, B. F.

AU - Pacharn, P.

AU - Thoeni, R. F.

AU - Lu, Y.

AU - Qayyum, Aliya

AU - Coakly, F.

AU - Gooding, C. A.

AU - Brasch, R. C.

PY - 2001

Y1 - 2001

N2 - OBJECTIVE. Focal fatty infiltration of the liver, a benign entity that can be confused with a malignant lesion, is well characterized in adults but not in children. The goal of this study was to determine by CT the prevalence and characteristics of focal fatty infiltration in children and young adults. MATERIALS AND METHODS. We retrospectively analyzed 305 consecutive contrast-enhanced abdominal CT examinations of 218 children and young adults with no known liver disease, performed during 2 years at our institution, to identify focal fatty infiltration of the liver. The imaging criterion for focal fatty infiltration of the liver on helical CT was a geometric or ovoid low-attenuation area adjacent to the falciform ligament, gallbladder fossa, or porta hepatis. If a patient's findings met the CT criterion for focal fatty infiltration of the liver, all previous abdominal CT and MR imaging examinations performed for that patient were reviewed to assess the evolution of focal fatty infiltration of the liver. RESULTS. Of 218 children and young adults, 20 (9.2%) met the CT criterion for focal fatty infiltration of the liver. In our population, focal fatty infiltration of the liver was identified only adjacent to the falciform ligament. The prevalence of focal fatty infiltration of the liver increased significantly with advancing age: 0% for ages 1 month-4 years; 7.3% for 5-9 years; 10.2% for 10-14 years, and 25.6% for 15-19 years (p < 0.0001). CONCLUSION. Focal fatty infiltration of the liver was identified in 9.2% of patients in our population, and occurrence of this lesion in children increases significantly with advancing age. However, focal fatty infiltration of the liver is uncommon in infants and young children and should be a diagnosis of exclusion.

AB - OBJECTIVE. Focal fatty infiltration of the liver, a benign entity that can be confused with a malignant lesion, is well characterized in adults but not in children. The goal of this study was to determine by CT the prevalence and characteristics of focal fatty infiltration in children and young adults. MATERIALS AND METHODS. We retrospectively analyzed 305 consecutive contrast-enhanced abdominal CT examinations of 218 children and young adults with no known liver disease, performed during 2 years at our institution, to identify focal fatty infiltration of the liver. The imaging criterion for focal fatty infiltration of the liver on helical CT was a geometric or ovoid low-attenuation area adjacent to the falciform ligament, gallbladder fossa, or porta hepatis. If a patient's findings met the CT criterion for focal fatty infiltration of the liver, all previous abdominal CT and MR imaging examinations performed for that patient were reviewed to assess the evolution of focal fatty infiltration of the liver. RESULTS. Of 218 children and young adults, 20 (9.2%) met the CT criterion for focal fatty infiltration of the liver. In our population, focal fatty infiltration of the liver was identified only adjacent to the falciform ligament. The prevalence of focal fatty infiltration of the liver increased significantly with advancing age: 0% for ages 1 month-4 years; 7.3% for 5-9 years; 10.2% for 10-14 years, and 25.6% for 15-19 years (p < 0.0001). CONCLUSION. Focal fatty infiltration of the liver was identified in 9.2% of patients in our population, and occurrence of this lesion in children increases significantly with advancing age. However, focal fatty infiltration of the liver is uncommon in infants and young children and should be a diagnosis of exclusion.

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