TY - JOUR
T1 - Frailty repels the knife
T2 - The impact of frailty index on surgical intervention and outcomes
AU - Handley, Katelyn F.
AU - Sood, Anil K.
AU - Molin, Graziela Zibetti Dal
AU - Westin, Shannon N.
AU - Meyer, Larissa A.
AU - Fellman, Bryan
AU - Soliman, Pamela T.
AU - Coleman, Robert L.
AU - Fleming, Nicole D.
N1 - Funding Information:
Relevant financial activities outside the supported work: NDF: Consultant/Advisory board (Tesaro, Pfizer); AKS: Consulting (Astra Zeneca, Merck, Kiyatec), research funding (M-Trap), shareholder (BioPath). SNW: Consulting (Agenus, AstraZeneca, Clovis Oncology, Eisai, GSK/Tesaro, Merck, Mereo, Novartis, Pfizer, Roche/Genentech, Zentalis), research funding (AstraZeneca, Bio-Path, Clovis Oncology, Cotinga Pharmaceuticals, GSK/Tesaro, Mereo, Novartis, Roche/Genentech). LAM: Consultant/Advisory board (Glasko-Kline Smith), research funding (AstraZeneca).
Funding Information:
This research was in part supported by the MD Anderson Ovarian Cancer Moon Shot and by the National Institutes of Health through MD Anderson's Cancer Center Support Grant ( P30CA016672 ; used the Clinical Trials Support Resource and the Biostatistics Resource Group), T32 training grant for gynecologic oncologists ( T32CA101642 ), and Ovarian Cancer SPORE funding ( CA217685 ), the Frank McGraw Memorial Chair in Cancer Research , and the American Cancer Society Research Professor Award . KFH is supported by a training fellowship from the Gulf Coast Consortia, on the Computational Cancer Biology Training Program (CPRIT Grant No. RP170593 ). SNW is supported by a GOG Foundation Scholar Investigator Award . LAM is supported by the National Institutes of Health/National Cancer Institute K07CA201013 .
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/7
Y1 - 2022/7
N2 - Objective: To assess the impact of frailty in patients with ovarian cancer on surgical procedures and outcomes. Methods: A retrospective review of patients with stage II-IV ovarian cancer from April 2013 to September 2017 was performed. Patients were triaged by laparoscopy to determine primary resectability. The adjusted modified frailty index score (amFI) was calculated and amFI ≥2 classified as high frailty. Clinical outcomes, progression free survival (PFS) and overall survival (OS) were estimated. Results: 592 patients met inclusion criteria; amFI of 0, 1 and ≥ 2 was noted in 57%, 29%, and 14%, respectively. Patients with high frailty were less likely to be offered laparoscopic assessment for primary surgery (49% v. 43% v. 28% for amFI = 0, 1, and ≥ 2, p = 0.004), and more likely to have a Fagotti score ≥ 8 (58%, 48%, and 34%, p = 0.04). Only 17% of the high frailty cohort had primary tumor reductive surgery compared to 26% and 34% in patients with amFI = 1 and amFI = 0 (p = 0.02). Furthermore, patients with higher amFI were less likely to undergo any tumor reductive surgery (85% v. 74% v. 59%, p < 0.001). Postoperative complications were more frequent in patients with higher amFI (44% v. 56% v. 64%, p = 0.01). Death within thirty days of treatment initiation was significantly higher in patients with high frailty (0.4% v. 2% v. 9%, p = 0.005). In multivariate analysis, high frailty was associated with worse PFS (p = 0.02) and OS (p < 0.05). Conclusions: Postoperative morbidity, PFS, and OS were worse in patients with high frailty scores. Quantification of frailty may be useful for clinical decision making in patients with newly diagnosed advanced ovarian cancer.
AB - Objective: To assess the impact of frailty in patients with ovarian cancer on surgical procedures and outcomes. Methods: A retrospective review of patients with stage II-IV ovarian cancer from April 2013 to September 2017 was performed. Patients were triaged by laparoscopy to determine primary resectability. The adjusted modified frailty index score (amFI) was calculated and amFI ≥2 classified as high frailty. Clinical outcomes, progression free survival (PFS) and overall survival (OS) were estimated. Results: 592 patients met inclusion criteria; amFI of 0, 1 and ≥ 2 was noted in 57%, 29%, and 14%, respectively. Patients with high frailty were less likely to be offered laparoscopic assessment for primary surgery (49% v. 43% v. 28% for amFI = 0, 1, and ≥ 2, p = 0.004), and more likely to have a Fagotti score ≥ 8 (58%, 48%, and 34%, p = 0.04). Only 17% of the high frailty cohort had primary tumor reductive surgery compared to 26% and 34% in patients with amFI = 1 and amFI = 0 (p = 0.02). Furthermore, patients with higher amFI were less likely to undergo any tumor reductive surgery (85% v. 74% v. 59%, p < 0.001). Postoperative complications were more frequent in patients with higher amFI (44% v. 56% v. 64%, p = 0.01). Death within thirty days of treatment initiation was significantly higher in patients with high frailty (0.4% v. 2% v. 9%, p = 0.005). In multivariate analysis, high frailty was associated with worse PFS (p = 0.02) and OS (p < 0.05). Conclusions: Postoperative morbidity, PFS, and OS were worse in patients with high frailty scores. Quantification of frailty may be useful for clinical decision making in patients with newly diagnosed advanced ovarian cancer.
KW - Frailty
KW - Ovarian cancer
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U2 - 10.1016/j.ygyno.2022.05.009
DO - 10.1016/j.ygyno.2022.05.009
M3 - Article
C2 - 35599168
AN - SCOPUS:85130455469
SN - 0090-8258
VL - 166
SP - 50
EP - 56
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -