TY - JOUR
T1 - Frequency and distribution of various rheumatic disorders associated with checkpoint inhibitor therapy
AU - Abdel-Wahab, Noha
AU - Suarez-Almazor, Maria E.
N1 - Funding Information:
Funding: This paper was published as part of a supplement funded by an educational grant from BMS.
Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Immune checkpoint inhibitors have advanced the treatment paradigm of various cancers, achieving remarkable survival benefits. However, a myriad of immune-related adverse events (irAE) has been recognized in almost every organ system, presumably because of persistent immune system activation. Rheumatic symptoms such as arthralgia or myalgia are very common. More specific irAE are increasingly being reported. The most frequent ones are inflammatory arthritis, polymyalgia-like syndromes, myositis and sicca manifestations. These rheumatic irAE can develop in ∼5-10% of patients treated with immune checkpoint inhibitors, although true incidence rates cannot be estimated given the lack of prospective cohort studies, and likely underreporting of rheumatic irAE in oncology trials. In this review, we will provide a summary of the epidemiologic data reported for these rheumatic irAE, until more robust prospective longitudinal studies become available to further define the true incidence rate of rheumatic irAE in patients receiving these novel cancer therapies.
AB - Immune checkpoint inhibitors have advanced the treatment paradigm of various cancers, achieving remarkable survival benefits. However, a myriad of immune-related adverse events (irAE) has been recognized in almost every organ system, presumably because of persistent immune system activation. Rheumatic symptoms such as arthralgia or myalgia are very common. More specific irAE are increasingly being reported. The most frequent ones are inflammatory arthritis, polymyalgia-like syndromes, myositis and sicca manifestations. These rheumatic irAE can develop in ∼5-10% of patients treated with immune checkpoint inhibitors, although true incidence rates cannot be estimated given the lack of prospective cohort studies, and likely underreporting of rheumatic irAE in oncology trials. In this review, we will provide a summary of the epidemiologic data reported for these rheumatic irAE, until more robust prospective longitudinal studies become available to further define the true incidence rate of rheumatic irAE in patients receiving these novel cancer therapies.
KW - cancer
KW - immune checkpoint inhibitors
KW - immune-related adverse events
KW - rheumatic syndromes
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U2 - 10.1093/rheumatology/kez297
DO - 10.1093/rheumatology/kez297
M3 - Article
C2 - 31816084
AN - SCOPUS:85076278190
SN - 1462-0324
VL - 58
SP - vii40-vii48
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
ER -