Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications

Mai Lin, Vincenzo Paolillo, Robert T. Ta, Jossana Damasco, Raniv Dawey Rojo, James C. Carl, Marites P. Melancon, Gregory C. Ravizzini, Dao B. Le, Elmer B. Santos

Research output: Contribution to journalArticle

Abstract

68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.

Original languageEnglish (US)
Article number108936
JournalApplied Radiation and Isotopes
Volume155
DOIs
StatePublished - Jan 2020

Fingerprint

level (quantity)
Cyclotrons
automation
cyclotrons
generators
Automation
preparation
metastasis
Imaging techniques
cancer
dosage

Keywords

  • Ga-PSMA-11
  • Automation
  • cGMP
  • Cyclotron
  • PET/CT

ASJC Scopus subject areas

  • Radiation

Cite this

Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications. / Lin, Mai; Paolillo, Vincenzo; Ta, Robert T.; Damasco, Jossana; Rojo, Raniv Dawey; Carl, James C.; Melancon, Marites P.; Ravizzini, Gregory C.; Le, Dao B.; Santos, Elmer B.

In: Applied Radiation and Isotopes, Vol. 155, 108936, 01.2020.

Research output: Contribution to journalArticle

Lin, Mai ; Paolillo, Vincenzo ; Ta, Robert T. ; Damasco, Jossana ; Rojo, Raniv Dawey ; Carl, James C. ; Melancon, Marites P. ; Ravizzini, Gregory C. ; Le, Dao B. ; Santos, Elmer B. / Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications. In: Applied Radiation and Isotopes. 2020 ; Vol. 155.
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abstract = "68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.",
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AU - Rojo, Raniv Dawey

AU - Carl, James C.

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