Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications

Mai Lin; Vincenzo Paolillo; Robert T. Ta; Jossana Damasco; Raniv Dawey Rojo; James C. Carl; Marites P. Melancon; Gregory C. Ravizzini; Dao B. Le; Elmer B. Santos

doi:10.1016/j.apradiso.2019.108936

Fully automated preparation of ⁶⁸Ga-PSMA-11 at curie level quantity using cyclotron-produced ⁶⁸Ga for clinical applications

Mai Lin, Vincenzo Paolillo, Robert T. Ta, Jossana Damasco, Raniv Dawey Rojo, James C. Carl, Marites P. Melancon, Gregory C. Ravizzini, Dao B. Le, Elmer B. Santos

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

⁶⁸Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of ⁶⁸Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available ⁶⁸Ge/⁶⁸Ga generator. ⁶⁸Ge/⁶⁸Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of ⁶⁸Ga/⁶⁸Ge generators has not been able to meet the increasing demand of ⁶⁸Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing ⁶⁸Ga-PSMA-11, using cyclotron-produced ⁶⁸Ga that is ready for routine clinical practice.

Original language	English (US)
Article number	108936
Journal	Applied Radiation and Isotopes
Volume	155
DOIs	https://doi.org/10.1016/j.apradiso.2019.108936
State	Published - Jan 2020

Keywords

Automation
Cyclotron
Ga-PSMA-11
PET/CT
cGMP

ASJC Scopus subject areas

Radiation

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility

Access to Document

10.1016/j.apradiso.2019.108936

Cite this

Lin, M., Paolillo, V., Ta, R. T., Damasco, J., Rojo, R. D., Carl, J. C., Melancon, M. P., Ravizzini, G. C., Le, D. B., & Santos, E. B. (2020). Fully automated preparation of ⁶⁸Ga-PSMA-11 at curie level quantity using cyclotron-produced ⁶⁸Ga for clinical applications. Applied Radiation and Isotopes, 155, Article 108936. https://doi.org/10.1016/j.apradiso.2019.108936

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title = "Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications",

abstract = "68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.",

keywords = "Automation, Cyclotron, Ga-PSMA-11, PET/CT, cGMP",

author = "Mai Lin and Vincenzo Paolillo and Ta, {Robert T.} and Jossana Damasco and Rojo, {Raniv Dawey} and Carl, {James C.} and Melancon, {Marites P.} and Ravizzini, {Gregory C.} and Le, {Dao B.} and Santos, {Elmer B.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

month = jan,

doi = "10.1016/j.apradiso.2019.108936",

language = "English (US)",

volume = "155",

journal = "Applied Radiation and Isotopes",

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AU - Lin, Mai

AU - Paolillo, Vincenzo

AU - Ta, Robert T.

AU - Damasco, Jossana

AU - Rojo, Raniv Dawey

AU - Carl, James C.

AU - Melancon, Marites P.

AU - Ravizzini, Gregory C.

AU - Le, Dao B.

AU - Santos, Elmer B.

PY - 2020/1

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N2 - 68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.

AB - 68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.

KW - Automation

KW - Cyclotron

KW - Ga-PSMA-11

KW - PET/CT

KW - cGMP

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Fully automated preparation of ⁶⁸Ga-PSMA-11 at curie level quantity using cyclotron-produced ⁶⁸Ga for clinical applications

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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Cite this

Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this

Fully automated preparation of ⁶⁸Ga-PSMA-11 at curie level quantity using cyclotron-produced ⁶⁸Ga for clinical applications