@inproceedings{c1d593bd4fcf4011a3990f94c59a2996,
title = "Functional assays of drug-target engagement on circulating tumor cells captured from patient blood correlate with patient progression",
abstract = "Chemotherapeutic treatment is limited by the heterogeneous and short-lived efficacy of therapy. Functional assays of tu-bulin bundling on microchip-captured circulating tumor cells (CTCs) in late-stage castrate-resistance prostate cancer are presented for the first time, and results are interpreted in the context of patient progression. Anti-PSMA capture leads to high capture rates of cells that remain functionally responsive to chemotherapies. These results point to the potential for microflu- idicallycaptured CTCs to inform clinical care in this patient population.",
keywords = "Antibody, CTC, Cancer, Chemotherapy, Circulating tumor cell, Clinical diagnostics, J591, Microfluidics, PSMA",
author = "Kirby, {Brian J.} and Pratt, {Erica D.} and Santana, {Steven M.} and Smith, {James P.} and Gleghorn, {Jason P.} and Mona Jodari and Ganjun Gakhar and Matt Loftus and He Liu and Bander, {Neil H.} and Nanus, {David M.} and Giannakakou, {Paraskevi A.}",
note = "Copyright: Copyright 2013 Elsevier B.V., All rights reserved.; 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
year = "2011",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "2068--2070",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
}