FYN promotes breast cancer progression through epithelial-mesenchymal transition

Ye Gong Xie, Yue Yu, Li Kun Hou, Xin Wang, Bin Zhang, Xu Chen Cao

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    15 Scopus citations

    Abstract

    FYN, one of the members of the Src family of kinases (SFKs), has been reported to be overexpressed in various types of cancers and correlated with cell motility and proliferation. However, the mechanism is still unclear. In the present study, we found that FYN was overexpressed in breast cancer and overexpression of FYN promoted cell proliferation, migration and invasion in the MCF10A cells, whereas depletion of FYN suppressed cell proliferation, migration and invasion in the MDA-MB-231 cells. Moreover, FYN upregulated the expression of mesenchymal markers and epithelial-mesenchymal transition (EMT)-related transcription factors, and downregulated the expression of epithelial markers, suggesting that FYN induces EMT in breast cancer cells. Furthermore, FYN was transcriptionally regulated by FOXO1 and mediated FGF2-induced EMT through both the PI3K/AKT and ERK/MAPK pathways.

    Original languageEnglish (US)
    Pages (from-to)1000-1006
    Number of pages7
    JournalOncology reports
    Volume36
    Issue number2
    DOIs
    StatePublished - Aug 2016

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    Keywords

    • Breast cancer
    • Epidermal growth factor
    • Epithelial-mesenchymal transition
    • FYN
    • Fibroblast growth factor 2
    • Progression

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Xie, Y. G., Yu, Y., Hou, L. K., Wang, X., Zhang, B., & Cao, X. C. (2016). FYN promotes breast cancer progression through epithelial-mesenchymal transition. Oncology reports, 36(2), 1000-1006. https://doi.org/10.3892/or.2016.4894