Garlic enhances circulatory antioxidants during 7,12- dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

S. Balasenthil, S. Arivazhagan, S. Nagini

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The protective effect of garlic (Allium sativum Linn.) on circulatory lipid peroxidation and antioxidants was investigated during 7,12- dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis in male Syrian hamsters. Enhanced lipid peroxidation in the circulation of tumour-bearing animals was accompanied by a significant decrease in the levels of ascorbic acid, vitamin E, reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase. Administration of garlic extract significantly decreased lipid peroxidation with simultaneous depletion of antioxidants. We speculate that garlic exerts its protective effects by decreasing circulatory lipid peroxides and enhancing antioxidants.

Original languageEnglish (US)
Pages (from-to)429-433
Number of pages5
JournalJournal of Ethnopharmacology
Volume72
Issue number3
DOIs
StatePublished - Oct 2000

Fingerprint

Garlic
Cheek
Cricetinae
Carcinogenesis
Antioxidants
Lipid Peroxidation
9,10-Dimethyl-1,2-benzanthracene
Lipid Peroxides
Mesocricetus
Glutathione Peroxidase
Vitamin E
Catalase
Ascorbic Acid
Superoxide Dismutase
Glutathione
anthracene
Neoplasms

Keywords

  • Antioxidants
  • Chemoprevention
  • DMBA
  • Garlic
  • Lipid peroxidation
  • Oral cancer

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Garlic enhances circulatory antioxidants during 7,12- dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. / Balasenthil, S.; Arivazhagan, S.; Nagini, S.

In: Journal of Ethnopharmacology, Vol. 72, No. 3, 10.2000, p. 429-433.

Research output: Contribution to journalArticle

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