Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells

A. B. Deisseroth; J. J. Kavanagh; E. G. Hanania; S. Fu; S. M. Kornblau; E. Estey; M. Talpaz; H. M. Kantarjian; D. F. Claxton; C. L. Reading; D. A. Dixon; R. W. Anderson; G. Lopez-Berestein; F. A. Holmes; C. J. Logothetis; M. Andreeff; W. Benedict

Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells

A. B. Deisseroth, J. J. Kavanagh, E. G. Hanania, S. Fu, S. M. Kornblau, E. Estey, M. Talpaz, H. M. Kantarjian, D. F. Claxton, C. L. Reading, D. A. Dixon, R. W. Anderson, G. Lopez-Berestein, F. A. Holmes, C. J. Logothetis, M. Andreeff, W. Benedict

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

Original language	English (US)
Pages (from-to)	139-145
Number of pages	7
Journal	Cancer Bulletin
Volume	45
Issue number	2
State	Published - 1993

ASJC Scopus subject areas

Cancer Research

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Deisseroth, A. B., Kavanagh, J. J., Hanania, E. G., Fu, S., Kornblau, S. M., Estey, E., Talpaz, M., Kantarjian, H. M., Claxton, D. F., Reading, C. L., Dixon, D. A., Anderson, R. W., Lopez-Berestein, G., Holmes, F. A., Logothetis, C. J., Andreeff, M., & Benedict, W. (1993). Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells. Cancer Bulletin, 45(2), 139-145.

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title = "Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells",

abstract = "Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.",

author = "Deisseroth, {A. B.} and Kavanagh, {J. J.} and Hanania, {E. G.} and S. Fu and Kornblau, {S. M.} and E. Estey and M. Talpaz and Kantarjian, {H. M.} and Claxton, {D. F.} and Reading, {C. L.} and Dixon, {D. A.} and Anderson, {R. W.} and G. Lopez-Berestein and Holmes, {F. A.} and Logothetis, {C. J.} and M. Andreeff and W. Benedict",

year = "1993",

language = "English (US)",

volume = "45",

pages = "139--145",

journal = "Cancer Bulletin",

issn = "0740-820X",

publisher = "Medical Arts Publishing",

number = "2",

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TY - JOUR

T1 - Gene therapy

T2 - Chemoprotection, immunoenhancement, and modification of tumor cells

AU - Deisseroth, A. B.

AU - Kavanagh, J. J.

AU - Hanania, E. G.

AU - Fu, S.

AU - Kornblau, S. M.

AU - Estey, E.

AU - Talpaz, M.

AU - Kantarjian, H. M.

AU - Claxton, D. F.

AU - Reading, C. L.

AU - Dixon, D. A.

AU - Anderson, R. W.

AU - Lopez-Berestein, G.

AU - Holmes, F. A.

AU - Logothetis, C. J.

AU - Andreeff, M.

AU - Benedict, W.

PY - 1993

Y1 - 1993

N2 - Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

AB - Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

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UR - http://www.scopus.com/inward/citedby.url?scp=0027300464&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:0027300464

SN - 0740-820X

VL - 45

SP - 139

EP - 145

JO - Cancer Bulletin

JF - Cancer Bulletin

IS - 2

ER -

Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells

Abstract

ASJC Scopus subject areas

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