Genetic aberrations in soft tissue leiomyosarcoma

Jilong Yang; Xiaoling Du; Kexin Chen; Antti Ylipää; Alexander J.F. Lazar; Jonathan Trent; Dina Lev; Raphael Pollock; Xishan Hao; Kelly Hunt; Wei Zhang

doi:10.1016/j.canlet.2008.06.013

Genetic aberrations in soft tissue leiomyosarcoma

Jilong Yang, Xiaoling Du, Kexin Chen, Antti Ylipää, Alexander J.F. Lazar, Jonathan Trent, Dina Lev, Raphael Pollock, Xishan Hao, Kelly Hunt, Wei Zhang

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Cancer Letters
Volume	275
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2008.06.013
State	Published - Mar 8 2009

Keywords

Array CGH
Genetic alteration
Karyotype
Leiomyosarcoma
Sarcoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2008.06.013

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title = "Genetic aberrations in soft tissue leiomyosarcoma",

abstract = "Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.",

keywords = "Array CGH, Genetic alteration, Karyotype, Leiomyosarcoma, Sarcoma",

author = "Jilong Yang and Xiaoling Du and Kexin Chen and Antti Ylip{\"a}{\"a} and Lazar, {Alexander J.F.} and Jonathan Trent and Dina Lev and Raphael Pollock and Xishan Hao and Kelly Hunt and Wei Zhang",

note = "Funding Information: We thank Kathryn Hale in the Department of Scientific Publications for her editorial assistance. The work was partially supported by NIH Grants RO1 CA098570 (WZ) and K23CA109060 (JCT) and the UTMDACC Physician Scientist Program (AJL, JCT). ",

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doi = "10.1016/j.canlet.2008.06.013",

language = "English (US)",

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T1 - Genetic aberrations in soft tissue leiomyosarcoma

AU - Yang, Jilong

AU - Du, Xiaoling

AU - Chen, Kexin

AU - Ylipää, Antti

AU - Lazar, Alexander J.F.

AU - Trent, Jonathan

AU - Lev, Dina

AU - Pollock, Raphael

AU - Hao, Xishan

AU - Hunt, Kelly

AU - Zhang, Wei

N1 - Funding Information: We thank Kathryn Hale in the Department of Scientific Publications for her editorial assistance. The work was partially supported by NIH Grants RO1 CA098570 (WZ) and K23CA109060 (JCT) and the UTMDACC Physician Scientist Program (AJL, JCT).

PY - 2009/3/8

Y1 - 2009/3/8

N2 - Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.

AB - Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.

KW - Array CGH

KW - Genetic alteration

KW - Karyotype

KW - Leiomyosarcoma

KW - Sarcoma

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DO - 10.1016/j.canlet.2008.06.013

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VL - 275

SP - 1

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JO - Cancer Letters

JF - Cancer Letters

IS - 1

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Genetic aberrations in soft tissue leiomyosarcoma

Abstract

Keywords

ASJC Scopus subject areas

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