Genetic and biological hallmarks of colorectal cancer

Jiexi Li; Xingdi Ma; Deepavali Chakravarti; Shabnam Shalapour; Ronald A. DePinho

doi:10.1101/gad.348226.120

Genetic and biological hallmarks of colorectal cancer

Jiexi Li, Xingdi Ma, Deepavali Chakravarti, Shabnam Shalapour, Ronald A. DePinho

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Abstract

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.

Original language	English (US)
Pages (from-to)	787-820
Number of pages	34
Journal	Genes and Development
Volume	38
Issue number	11-12
DOIs	https://doi.org/10.1101/gad.348226.120
State	Published - Jun 1 2021

Keywords

CRC
Cancer genetics
Cancer therapy development
Colorectal cancer
Tumor microenviornment

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.348226.120

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title = "Genetic and biological hallmarks of colorectal cancer",

abstract = "Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.",

keywords = "CRC, Cancer genetics, Cancer therapy development, Colorectal cancer, Tumor microenviornment",

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T1 - Genetic and biological hallmarks of colorectal cancer

AU - Li, Jiexi

AU - Ma, Xingdi

AU - Chakravarti, Deepavali

AU - Shalapour, Shabnam

AU - DePinho, Ronald A.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.

AB - Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.

KW - CRC

KW - Cancer genetics

KW - Cancer therapy development

KW - Colorectal cancer

KW - Tumor microenviornment

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Genetic and biological hallmarks of colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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