TY - JOUR
T1 - Genetics of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)
AU - Oishi, Naoki
AU - Miranda, Roberto N.
AU - Feldman, Andrew L.
N1 - Funding Information:
This supplement is sponsored by Allergan plc (Dublin, Ireland), Aesthetic Surgery Education & Research Foundation (ASERF) (Garden Grove, CA), Establishment Labs (Alajuela, Costa Rica), Mentor Worldwide, LLC (Irvine, CA), Polytech Health & Aesthetics GmbH (Dieburg, Germany), and Sientra, Inc. (Santa Barbara, CA).
Publisher Copyright:
© 2019 The American Society for Aesthetic Plastic Surgery, Inc.
PY - 2019/1/31
Y1 - 2019/1/31
N2 - Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a newly included provisional entity in the 2016 revision of the World Health Organization classification, is a distinct form of CD30-positive T-cell non-Hodgkin lymphoma that arises in association with a breast implant after reconstructive or cosmetic surgery. In addition to its characteristic clinical presentation, recent studies using next-generation sequencing have revealed that BIA-ALCL has a unique pattern of genetic alterations. BIA-ALCL is consistently negative for ALCL-related gene rearrangements involving ALK, DUSP22, and TP63. However, the JAK-STAT3 pathway is constitutively activated in BIA-ALCL, which in some cases is associated with recurrent somatic mutations of JAK1 and/or STAT3. These activating mutations, which may be concurrent, are identified in 13% (3/23) and 26% (6/23) of BIA-ALCLs, respectively. Other genetic alterations include point mutations of DNMT3A and TP53. Although the number of examined cases has been limited, these findings suggest that BIA-ALCL shows more uniform molecular features than systemic and primary cutaneous ALCLs, which show considerable genetic heterogeneity. Targeted therapies inhibiting JAK-STAT signaling are being developed and may offer novel therapeutic options for patients with BIA-ALCL, especially those with advanced disease.
AB - Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a newly included provisional entity in the 2016 revision of the World Health Organization classification, is a distinct form of CD30-positive T-cell non-Hodgkin lymphoma that arises in association with a breast implant after reconstructive or cosmetic surgery. In addition to its characteristic clinical presentation, recent studies using next-generation sequencing have revealed that BIA-ALCL has a unique pattern of genetic alterations. BIA-ALCL is consistently negative for ALCL-related gene rearrangements involving ALK, DUSP22, and TP63. However, the JAK-STAT3 pathway is constitutively activated in BIA-ALCL, which in some cases is associated with recurrent somatic mutations of JAK1 and/or STAT3. These activating mutations, which may be concurrent, are identified in 13% (3/23) and 26% (6/23) of BIA-ALCLs, respectively. Other genetic alterations include point mutations of DNMT3A and TP53. Although the number of examined cases has been limited, these findings suggest that BIA-ALCL shows more uniform molecular features than systemic and primary cutaneous ALCLs, which show considerable genetic heterogeneity. Targeted therapies inhibiting JAK-STAT signaling are being developed and may offer novel therapeutic options for patients with BIA-ALCL, especially those with advanced disease.
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U2 - 10.1093/asj/sjy311
DO - 10.1093/asj/sjy311
M3 - Article
C2 - 30715169
AN - SCOPUS:85061033837
SN - 1090-820X
VL - 39
SP - S14-S20
JO - Aesthetic surgery journal
JF - Aesthetic surgery journal
ER -