Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: Assignment of a susceptibility gene to mouse chromosome 7

Treatment of young AKR/J mice with N-methyl-N-nitrosourea (MNU) results in the induction of a high incidence of thymic lymphomas occurring between 4 and 6 months of age. The tumor incidence is higher and the latency period is shorter than that observed in other MNU-treated mouse strains. Analysis of tumor incidence in crosses of AKR/J with C57L/J mice indicates that several genes influence the incidence and latency of MNU-induced thymic lymphomas. One of these genes appears to be tightly linked to the albino locus of chromosome 7. [J Natl Cancer Inst 81:1652-1655, 1989]