Genetics of Pancreatic Neoplasms and Role of Screening

Venkata S. Katabathina, Omid Y. Rikhtehgar, Anil K. Dasyam, Rohan Manickam, Srinivasa R. Prasad

    Research output: Contribution to journalReview articlepeer-review

    9 Scopus citations

    Abstract

    There is a wide spectrum of pancreatic neoplasms with characteristic genetic abnormalities, tumor pathways, and histopathology that primarily determine tumor biology, treatment response, and prognosis. Although most pancreatic tumors are sporadic, 10% of neoplasms occur in the setting of distinct hereditary syndromes. Detailed studies of these rare syndromes have allowed researchers to identify a myriad of specific genetic signatures of pancreatic tumors. A better understanding of tumor genomics may have significant clinical implications in the diagnosis and management of patients with pancreatic tumors. Evolving knowledge has paved the way to screening paradigms and protocols in individuals at higher risk of developing pancreatic tumors.

    Original languageEnglish (US)
    Pages (from-to)375-389
    Number of pages15
    JournalMagnetic resonance imaging clinics of North America
    Volume26
    Issue number3
    DOIs
    StatePublished - Aug 2018

    Keywords

    • Genomics
    • Neuroendocrine neoplasm
    • Pancreatic ductal adenocarcinoma
    • Screening
    • Serous cystadenoma
    • Solid-pseudopapillary tumor

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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