Genetics of the mouse

Jean Louis Guénet, Fernando Benavides, Jean Jacques Panthier, Xavier Montagutelli

Research output: Book/ReportBook

5 Scopus citations

Abstract

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Original languageEnglish (US)
PublisherSpringer Berlin Heidelberg
Number of pages408
ISBN (Electronic)9783662442876
ISBN (Print)9783662442869
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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