TY - JOUR
T1 - Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridization
AU - Hameed, Meera
AU - Ulger, Celal
AU - Yasar, Duygu
AU - Limaye, Neha
AU - Kurvathi, Rohini
AU - Streck, Deanna
AU - Benevenia, Joseph
AU - Patterson, Francis
AU - Dermody, James J.
AU - Toruner, Gokce A.
N1 - Funding Information:
This project was funded in part by the Ruth Estrin Goldberg Foundation.
PY - 2009/7/15
Y1 - 2009/7/15
N2 - Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades.
AB - Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There was a statistically significant association between high-grade tumor (grade III and dedifferentiated) and the recurrent genetic deletions at 5q14.2∼q21.3, 6q16∼q25.3, 9p24.2∼q12, and 9p21.3. There is consistency between increased levels of aneuploidy and the progression of chondrosarcoma from lower to higher grades.
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U2 - 10.1016/j.cancergencyto.2009.03.009
DO - 10.1016/j.cancergencyto.2009.03.009
M3 - Article
C2 - 19596254
AN - SCOPUS:67649808099
SN - 0165-4608
VL - 192
SP - 56
EP - 59
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -