Genomic heterogeneity of multiple synchronous lung cancer

Yu Liu; Jianjun Zhang; Lin Li; Guangliang Yin; Jianhua Zhang; Shan Zheng; Hannah Cheung; Ning Wu; Ning Lu; Xizeng Mao; Longhai Yang; Jiexin Zhang; Li Zhang; Sahil Seth; Huang Chen; Xingzhi Song; Kan Liu; Yongqiang Xie; Lina Zhou; Chuanduo Zhao; Naijun Han; Wenting Chen; Susu Zhang; Longyun Chen; Wenjun Cai; Miaozhong Shen; Ningzhi Xu; Shujun Cheng; Huanming Yang; J. Jack Lee; Arlene Correa; Junya Fujimoto; Carmen Behrens; Chi Wan Chow; William N. William; John V. Heymach; Waun Ki Hong; Stephen Swisher; Ignacio I. Wistuba; Jun Wang; Dongmei Lin; Xiangyang Liu; P. Andrew Futreal; Yanning Gao

doi:10.1038/ncomms13200

Genomic heterogeneity of multiple synchronous lung cancer

Yu Liu, Jianjun Zhang, Lin Li, Guangliang Yin, Jianhua Zhang, Shan Zheng, Hannah Cheung, Ning Wu, Ning Lu, Xizeng Mao, Longhai Yang, Jiexin Zhang, Li Zhang, Sahil Seth, Huang Chen, Xingzhi Song, Kan Liu, Yongqiang Xie, Lina Zhou, Chuanduo ZhaoNaijun Han, Wenting Chen, Susu Zhang, Longyun Chen, Wenjun Cai, Miaozhong Shen, Ningzhi Xu, Shujun Cheng, Huanming Yang, J. Jack Lee, Arlene Correa, Junya Fujimoto, Carmen Behrens, Chi Wan Chow, William N. William, John V. Heymach, Waun Ki Hong, Stephen Swisher, Ignacio I. Wistuba, Jun Wang, Dongmei Lin, Xiangyang Liu, P. Andrew Futreal, Yanning Gao

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Abstract

Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

Original language	English (US)
Article number	13200
Journal	Nature communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms13200
State	Published - Oct 21 2016

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1038/ncomms13200

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Liu, Y, Zhang, J, Li, L, Yin, G, Zhang, J, Zheng, S, Cheung, H, Wu, N, Lu, N, Mao, X, Yang, L, Zhang, J, Zhang, L, Seth, S, Chen, H, Song, X, Liu, K, Xie, Y, Zhou, L, Zhao, C, Han, N, Chen, W, Zhang, S, Chen, L, Cai, W, Shen, M, Xu, N, Cheng, S, Yang, H, Lee, JJ , Correa, A, Fujimoto, J, Behrens, C, Chow, CW, William, WN, Heymach, JV, Hong, WK, Swisher, S , Wistuba, II, Wang, J, Lin, D, Liu, X, Futreal, PA & Gao, Y 2016, 'Genomic heterogeneity of multiple synchronous lung cancer', Nature communications, vol. 7, 13200. https://doi.org/10.1038/ncomms13200

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abstract = "Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.",

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AU - Liu, Yu

AU - Zhang, Jianjun

AU - Li, Lin

AU - Yin, Guangliang

AU - Zhang, Jianhua

AU - Zheng, Shan

AU - Cheung, Hannah

AU - Wu, Ning

AU - Lu, Ning

AU - Mao, Xizeng

AU - Yang, Longhai

AU - Zhang, Jiexin

AU - Zhang, Li

AU - Seth, Sahil

AU - Chen, Huang

AU - Song, Xingzhi

AU - Liu, Kan

AU - Xie, Yongqiang

AU - Zhou, Lina

AU - Zhao, Chuanduo

AU - Han, Naijun

AU - Chen, Wenting

AU - Zhang, Susu

AU - Chen, Longyun

AU - Cai, Wenjun

AU - Shen, Miaozhong

AU - Xu, Ningzhi

AU - Cheng, Shujun

AU - Yang, Huanming

AU - Lee, J. Jack

AU - Correa, Arlene

AU - Fujimoto, Junya

AU - Behrens, Carmen

AU - Chow, Chi Wan

AU - William, William N.

AU - Heymach, John V.

AU - Hong, Waun Ki

AU - Swisher, Stephen

AU - Wistuba, Ignacio I.

AU - Wang, Jun

AU - Lin, Dongmei

AU - Liu, Xiangyang

AU - Futreal, P. Andrew

AU - Gao, Yanning

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N2 - Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

AB - Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

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Genomic heterogeneity of multiple synchronous lung cancer

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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