Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Kenneth Aldape; Samirkumar B. Amin; David M. Ashley; Jill S. Barnholtz-Sloan; Amanda J. Bates; Rameen Beroukhim; Christoph Bock; Daniel J. Brat; Elizabeth B. Claus; Joseph F. Costello; John F. de Groot; Gaetano Finocchiaro; Pim J. French; Hui K. Gan; Brent Griffith; Christel C. Herold-Mende; Craig Horbinski; Antonio Iavarone; Steven N. Kalkanis; Konstantina Karabatsou; Hoon Kim; Mathilde C.M. Kouwenhoven; Kerrie L. McDonald; Hrvoje Miletic; Do Hyun Nam; Ho Keung Ng; Simone P. Niclou; Houtan Noushmehr; D. Ryan Ormond; Laila M. Poisson; Guido Reifenberger; Federico Roncaroli; Jason K. Sa; Peter A.E. Sillevis Smitt; Marion Smits; Camila F. Souza; Ghazaleh Tabatabai; Erwin G. Van Meir; Roel G.W. Verhaak; Colin Watts; Pieter Wesseling; Adelheid Woehrer; W. K. Alfred Yung; Christine Jungk; Ann Christin Hau; Eric van Dyck; Bart A. Westerman; Julia Yin; Olajide Abiola; Nikolaj Zeps; Sean Grimmond; Michael Buckland; Mustafa Khasraw; Erik P. Sulman; Andrea M. Muscat; Lucy Stead

doi:10.1093/neuonc/noy020

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Kenneth Aldape, Samirkumar B. Amin, David M. Ashley, Jill S. Barnholtz-Sloan, Amanda J. Bates, Rameen Beroukhim, Christoph Bock, Daniel J. Brat, Elizabeth B. Claus, Joseph F. Costello, John F. de Groot, Gaetano Finocchiaro, Pim J. French, Hui K. Gan, Brent Griffith, Christel C. Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N. Kalkanis, Konstantina KarabatsouHoon Kim, Mathilde C.M. Kouwenhoven, Kerrie L. McDonald, Hrvoje Miletic, Do Hyun Nam, Ho Keung Ng, Simone P. Niclou, Houtan Noushmehr, D. Ryan Ormond, Laila M. Poisson, Guido Reifenberger, Federico Roncaroli, Jason K. Sa, Peter A.E. Sillevis Smitt, Marion Smits, Camila F. Souza, Ghazaleh Tabatabai, Erwin G. Van Meir, Roel G.W. Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, W. K. Alfred Yung, Christine Jungk, Ann Christin Hau, Eric van Dyck, Bart A. Westerman, Julia Yin, Olajide Abiola, Nikolaj Zeps, Sean Grimmond, Michael Buckland, Mustafa Khasraw, Erik P. Sulman, Andrea M. Muscat, Lucy Stead

Research output: Contribution to journal › Article › peer-review

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Abstract

Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.

Original language	English (US)
Pages (from-to)	873-884
Number of pages	12
Journal	Neuro-oncology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1093/neuonc/noy020
State	Published - Jun 18 2018

Keywords

characterization
evolution
glioma
sequencing
subtypes

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1093/neuonc/noy020

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Aldape, K., Amin, S. B., Ashley, D. M., Barnholtz-Sloan, J. S., Bates, A. J., Beroukhim, R., Bock, C., Brat, D. J., Claus, E. B., Costello, J. F., de Groot, J. F., Finocchiaro, G., French, P. J., Gan, H. K., Griffith, B., Herold-Mende, C. C., Horbinski, C., Iavarone, A., Kalkanis, S. N., ... Stead, L. (2018). Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. Neuro-oncology, 20(7), 873-884. https://doi.org/10.1093/neuonc/noy020

Aldape, K, Amin, SB, Ashley, DM, Barnholtz-Sloan, JS, Bates, AJ, Beroukhim, R, Bock, C, Brat, DJ, Claus, EB, Costello, JF, de Groot, JF, Finocchiaro, G, French, PJ, Gan, HK, Griffith, B, Herold-Mende, CC, Horbinski, C, Iavarone, A, Kalkanis, SN, Karabatsou, K, Kim, H, Kouwenhoven, MCM, McDonald, KL, Miletic, H, Nam, DH, Ng, HK, Niclou, SP, Noushmehr, H, Ryan Ormond, D, Poisson, LM, Reifenberger, G, Roncaroli, F, Sa, JK, Sillevis Smitt, PAE, Smits, M, Souza, CF, Tabatabai, G, Van Meir, EG, Verhaak, RGW, Watts, C, Wesseling, P, Woehrer, A, Alfred Yung, WK, Jungk, C, Hau, AC, van Dyck, E, Westerman, BA, Yin, J, Abiola, O, Zeps, N, Grimmond, S, Buckland, M, Khasraw, M, Sulman, EP, Muscat, AM & Stead, L 2018, 'Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium', Neuro-oncology, vol. 20, no. 7, pp. 873-884. https://doi.org/10.1093/neuonc/noy020

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abstract = "Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.",

keywords = "characterization, evolution, glioma, sequencing, subtypes",

author = "Kenneth Aldape and Amin, {Samirkumar B.} and Ashley, {David M.} and Barnholtz-Sloan, {Jill S.} and Bates, {Amanda J.} and Rameen Beroukhim and Christoph Bock and Brat, {Daniel J.} and Claus, {Elizabeth B.} and Costello, {Joseph F.} and {de Groot}, {John F.} and Gaetano Finocchiaro and French, {Pim J.} and Gan, {Hui K.} and Brent Griffith and Herold-Mende, {Christel C.} and Craig Horbinski and Antonio Iavarone and Kalkanis, {Steven N.} and Konstantina Karabatsou and Hoon Kim and Kouwenhoven, {Mathilde C.M.} and McDonald, {Kerrie L.} and Hrvoje Miletic and Nam, {Do Hyun} and Ng, {Ho Keung} and Niclou, {Simone P.} and Houtan Noushmehr and {Ryan Ormond}, D. and Poisson, {Laila M.} and Guido Reifenberger and Federico Roncaroli and Sa, {Jason K.} and {Sillevis Smitt}, {Peter A.E.} and Marion Smits and Souza, {Camila F.} and Ghazaleh Tabatabai and {Van Meir}, {Erwin G.} and Verhaak, {Roel G.W.} and Colin Watts and Pieter Wesseling and Adelheid Woehrer and {Alfred Yung}, {W. K.} and Christine Jungk and Hau, {Ann Christin} and {van Dyck}, Eric and Westerman, {Bart A.} and Julia Yin and Olajide Abiola and Nikolaj Zeps and Sean Grimmond and Michael Buckland and Mustafa Khasraw and Sulman, {Erik P.} and Muscat, {Andrea M.} and Lucy Stead",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.",

year = "2018",

month = jun,

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doi = "10.1093/neuonc/noy020",

language = "English (US)",

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T2 - Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

AU - Aldape, Kenneth

AU - Amin, Samirkumar B.

AU - Ashley, David M.

AU - Barnholtz-Sloan, Jill S.

AU - Bates, Amanda J.

AU - Beroukhim, Rameen

AU - Bock, Christoph

AU - Brat, Daniel J.

AU - Claus, Elizabeth B.

AU - Costello, Joseph F.

AU - de Groot, John F.

AU - Finocchiaro, Gaetano

AU - French, Pim J.

AU - Gan, Hui K.

AU - Griffith, Brent

AU - Herold-Mende, Christel C.

AU - Horbinski, Craig

AU - Iavarone, Antonio

AU - Kalkanis, Steven N.

AU - Karabatsou, Konstantina

AU - Kim, Hoon

AU - Kouwenhoven, Mathilde C.M.

AU - McDonald, Kerrie L.

AU - Miletic, Hrvoje

AU - Nam, Do Hyun

AU - Ng, Ho Keung

AU - Niclou, Simone P.

AU - Noushmehr, Houtan

AU - Ryan Ormond, D.

AU - Poisson, Laila M.

AU - Reifenberger, Guido

AU - Roncaroli, Federico

AU - Sa, Jason K.

AU - Sillevis Smitt, Peter A.E.

AU - Smits, Marion

AU - Souza, Camila F.

AU - Tabatabai, Ghazaleh

AU - Van Meir, Erwin G.

AU - Verhaak, Roel G.W.

AU - Watts, Colin

AU - Wesseling, Pieter

AU - Woehrer, Adelheid

AU - Alfred Yung, W. K.

AU - Jungk, Christine

AU - Hau, Ann Christin

AU - van Dyck, Eric

AU - Westerman, Bart A.

AU - Yin, Julia

AU - Abiola, Olajide

AU - Zeps, Nikolaj

AU - Grimmond, Sean

AU - Buckland, Michael

AU - Khasraw, Mustafa

AU - Sulman, Erik P.

AU - Muscat, Andrea M.

AU - Stead, Lucy

PY - 2018/6/18

Y1 - 2018/6/18

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AB - Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.

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KW - evolution

KW - glioma

KW - sequencing

KW - subtypes

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Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Abstract

Keywords

ASJC Scopus subject areas

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