GPR56: GPCR as a guardian against ferroptosis

Yuelong Yan; Li Zhuang; Boyi Gan

doi:10.1016/j.cmet.2024.08.011

GPR56: GPCR as a guardian against ferroptosis

Yuelong Yan, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis—a form of cell death—and effectively mitigate ferroptosis-associated liver damage.

Original language	English (US)
Pages (from-to)	2355-2356
Number of pages	2
Journal	Cell Metabolism
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/j.cmet.2024.08.011
State	Published - Nov 5 2024

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2024.08.011

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title = "GPR56: GPCR as a guardian against ferroptosis",

abstract = "Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis—a form of cell death—and effectively mitigate ferroptosis-associated liver damage.",

author = "Yuelong Yan and Li Zhuang and Boyi Gan",

note = "Publisher Copyright: {\textcopyright} 2024",

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language = "English (US)",

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T2 - GPCR as a guardian against ferroptosis

AU - Yan, Yuelong

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2024/11/5

Y1 - 2024/11/5

N2 - Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis—a form of cell death—and effectively mitigate ferroptosis-associated liver damage.

AB - Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis—a form of cell death—and effectively mitigate ferroptosis-associated liver damage.

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DO - 10.1016/j.cmet.2024.08.011

M3 - Comment/debate

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JO - Cell Metabolism

JF - Cell Metabolism

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GPR56: GPCR as a guardian against ferroptosis

Abstract

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