Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019

Emmanuel Melloul; Kristoffer Lassen; Didier Roulin; Fabian Grass; Julie Perinel; Mustapha Adham; Erik Björn Wellge; Filipe Kunzler; Marc G. Besselink; Horacio Asbun; Michael J. Scott; Cornelis H.C. Dejong; Dionisos Vrochides; Thomas Aloia; Jakob R. Izbicki; Nicolas Demartines

doi:10.1007/s00268-020-05462-w

Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019

Emmanuel Melloul, Kristoffer Lassen, Didier Roulin, Fabian Grass, Julie Perinel, Mustapha Adham, Erik Björn Wellge, Filipe Kunzler, Marc G. Besselink, Horacio Asbun, Michael J. Scott, Cornelis H.C. Dejong, Dionisos Vrochides, Thomas Aloia, Jakob R. Izbicki, Nicolas Demartines

Surgical Oncology

Research output: Contribution to journal › Review article › peer-review

237 Scopus citations

Abstract

Background: Enhanced recovery after surgery (ERAS) pathways are now implemented worldwide with strong evidence that adhesion to such protocol reduces medical complications, costs and hospital stay. This concept has been applied for pancreatic surgery since the first published guidelines in 2012. This study presents the updated ERAS recommendations for pancreatoduodenectomy (PD) based on the best available evidence and on expert consensus. Methods: A systematic literature search was conducted in three databases (Embase, Medline Ovid and Cochrane Library Wiley) for the 27 developed ERAS items. Quality of randomized trials was assessed using the Consolidated Standards of Reporting Trials statement checklist. The level of evidence for each item was determined using the Grading of Recommendations Assessment Development and Evaluation system. The Delphi method was used to validate the final recommendations. Results: A total of 314 articles were included in the systematic review. Consensus among experts was reached after three rounds. A well-implemented ERAS protocol with good compliance is associated with a reduction in medical complications and length of hospital stay. The highest level of evidence was available for five items: avoiding hypothermia, use of wound catheters as an alternative to epidural analgesia, antimicrobial and thromboprophylaxis protocols and preoperative nutritional interventions for patients with severe weight loss (> 15%). Conclusions: The current updated ERAS recommendations for PD are based on the best available evidence and processed by the Delphi method. Prospective studies of high quality are encouraged to confirm the benefit of current updated recommendations.

Original language	English (US)
Pages (from-to)	2056-2084
Number of pages	29
Journal	World journal of surgery
Volume	44
Issue number	7
DOIs	https://doi.org/10.1007/s00268-020-05462-w
State	Published - Jul 1 2020

ASJC Scopus subject areas

Surgery

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Melloul, E., Lassen, K., Roulin, D., Grass, F., Perinel, J., Adham, M., Wellge, E. B., Kunzler, F., Besselink, M. G., Asbun, H., Scott, M. J., Dejong, C. H. C., Vrochides, D., Aloia, T., Izbicki, J. R., & Demartines, N. (2020). Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019. World journal of surgery, 44(7), 2056-2084. https://doi.org/10.1007/s00268-020-05462-w

Melloul, E, Lassen, K, Roulin, D, Grass, F, Perinel, J, Adham, M, Wellge, EB, Kunzler, F, Besselink, MG, Asbun, H, Scott, MJ, Dejong, CHC, Vrochides, D, Aloia, T, Izbicki, JR & Demartines, N 2020, 'Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019', World journal of surgery, vol. 44, no. 7, pp. 2056-2084. https://doi.org/10.1007/s00268-020-05462-w

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title = "Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019",

abstract = "Background: Enhanced recovery after surgery (ERAS) pathways are now implemented worldwide with strong evidence that adhesion to such protocol reduces medical complications, costs and hospital stay. This concept has been applied for pancreatic surgery since the first published guidelines in 2012. This study presents the updated ERAS recommendations for pancreatoduodenectomy (PD) based on the best available evidence and on expert consensus. Methods: A systematic literature search was conducted in three databases (Embase, Medline Ovid and Cochrane Library Wiley) for the 27 developed ERAS items. Quality of randomized trials was assessed using the Consolidated Standards of Reporting Trials statement checklist. The level of evidence for each item was determined using the Grading of Recommendations Assessment Development and Evaluation system. The Delphi method was used to validate the final recommendations. Results: A total of 314 articles were included in the systematic review. Consensus among experts was reached after three rounds. A well-implemented ERAS protocol with good compliance is associated with a reduction in medical complications and length of hospital stay. The highest level of evidence was available for five items: avoiding hypothermia, use of wound catheters as an alternative to epidural analgesia, antimicrobial and thromboprophylaxis protocols and preoperative nutritional interventions for patients with severe weight loss (> 15%). Conclusions: The current updated ERAS recommendations for PD are based on the best available evidence and processed by the Delphi method. Prospective studies of high quality are encouraged to confirm the benefit of current updated recommendations.",

author = "Emmanuel Melloul and Kristoffer Lassen and Didier Roulin and Fabian Grass and Julie Perinel and Mustapha Adham and Wellge, {Erik Bj{\"o}rn} and Filipe Kunzler and Besselink, {Marc G.} and Horacio Asbun and Scott, {Michael J.} and Dejong, {Cornelis H.C.} and Dionisos Vrochides and Thomas Aloia and Izbicki, {Jakob R.} and Nicolas Demartines",

note = "Publisher Copyright: {\textcopyright} 2020, Soci{\'e}t{\'e} Internationale de Chirurgie.",

year = "2020",

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doi = "10.1007/s00268-020-05462-w",

language = "English (US)",

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TY - JOUR

T1 - Guidelines for Perioperative Care for Pancreatoduodenectomy

T2 - Enhanced Recovery After Surgery (ERAS) Recommendations 2019

AU - Melloul, Emmanuel

AU - Lassen, Kristoffer

AU - Roulin, Didier

AU - Grass, Fabian

AU - Perinel, Julie

AU - Adham, Mustapha

AU - Wellge, Erik Björn

AU - Kunzler, Filipe

AU - Besselink, Marc G.

AU - Asbun, Horacio

AU - Scott, Michael J.

AU - Dejong, Cornelis H.C.

AU - Vrochides, Dionisos

AU - Aloia, Thomas

AU - Izbicki, Jakob R.

AU - Demartines, Nicolas

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Background: Enhanced recovery after surgery (ERAS) pathways are now implemented worldwide with strong evidence that adhesion to such protocol reduces medical complications, costs and hospital stay. This concept has been applied for pancreatic surgery since the first published guidelines in 2012. This study presents the updated ERAS recommendations for pancreatoduodenectomy (PD) based on the best available evidence and on expert consensus. Methods: A systematic literature search was conducted in three databases (Embase, Medline Ovid and Cochrane Library Wiley) for the 27 developed ERAS items. Quality of randomized trials was assessed using the Consolidated Standards of Reporting Trials statement checklist. The level of evidence for each item was determined using the Grading of Recommendations Assessment Development and Evaluation system. The Delphi method was used to validate the final recommendations. Results: A total of 314 articles were included in the systematic review. Consensus among experts was reached after three rounds. A well-implemented ERAS protocol with good compliance is associated with a reduction in medical complications and length of hospital stay. The highest level of evidence was available for five items: avoiding hypothermia, use of wound catheters as an alternative to epidural analgesia, antimicrobial and thromboprophylaxis protocols and preoperative nutritional interventions for patients with severe weight loss (> 15%). Conclusions: The current updated ERAS recommendations for PD are based on the best available evidence and processed by the Delphi method. Prospective studies of high quality are encouraged to confirm the benefit of current updated recommendations.

AB - Background: Enhanced recovery after surgery (ERAS) pathways are now implemented worldwide with strong evidence that adhesion to such protocol reduces medical complications, costs and hospital stay. This concept has been applied for pancreatic surgery since the first published guidelines in 2012. This study presents the updated ERAS recommendations for pancreatoduodenectomy (PD) based on the best available evidence and on expert consensus. Methods: A systematic literature search was conducted in three databases (Embase, Medline Ovid and Cochrane Library Wiley) for the 27 developed ERAS items. Quality of randomized trials was assessed using the Consolidated Standards of Reporting Trials statement checklist. The level of evidence for each item was determined using the Grading of Recommendations Assessment Development and Evaluation system. The Delphi method was used to validate the final recommendations. Results: A total of 314 articles were included in the systematic review. Consensus among experts was reached after three rounds. A well-implemented ERAS protocol with good compliance is associated with a reduction in medical complications and length of hospital stay. The highest level of evidence was available for five items: avoiding hypothermia, use of wound catheters as an alternative to epidural analgesia, antimicrobial and thromboprophylaxis protocols and preoperative nutritional interventions for patients with severe weight loss (> 15%). Conclusions: The current updated ERAS recommendations for PD are based on the best available evidence and processed by the Delphi method. Prospective studies of high quality are encouraged to confirm the benefit of current updated recommendations.

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U2 - 10.1007/s00268-020-05462-w

DO - 10.1007/s00268-020-05462-w

M3 - Review article

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AN - SCOPUS:85081884028

SN - 0364-2313

VL - 44

SP - 2056

EP - 2084

JO - World journal of surgery

JF - World journal of surgery

IS - 7

ER -

Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019

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