TY - JOUR
T1 - Guidelines for the prevention of intravascular catheter-related infections
AU - O'Grady, Naomi P.
AU - Alexander, Mary
AU - Dellinger, E. Patchen
AU - Gerberding, Julie L.
AU - Heard, Stephen O.
AU - Maki, Dennis G.
AU - Masur, Henry
AU - McCormick, Rita D.
AU - Mermel, Leonard A.
AU - Pearson, Michele L.
AU - Raad, Issam I.
AU - Randolph, Adrienne
AU - Weinstein, Robert A.
AU - Siegel, Jane D.
AU - Chinn, Raymond Y.W.
AU - DeMaria, Alfred
AU - Lee, James T.
AU - Rutala, William A.
AU - Larson, Elaine L.
AU - Moncada, Ramon E.
AU - Scheckler, William E.
AU - Stover, Beth H.
AU - Underwood, Marjorie A.
N1 - Funding Information:
Dennis Maki : Research grant from Arrow, 3M, Becton Dickinson, Johnson and Johnson; consultant for Micrologix Issam Raad : Holds 2 patents associated with minocycline-rifampin catheters. Patents are the property of University of Texas, MD Anderson Cancer Center, Baylor College of Medicine, and Wake Forest University. Both patents are licensed to Cook Critical Care with royalty rights to the institutions involved, with a percentage of royalties to the inventors. Coinventor of patents associated with minocycline-EDTA flush solution. These patents are not yet licensed. Grant and research support from Kimberly Clark, Becton Dickinson, Abbott Labs, Immunomedics, and Cook Critical Care, Inc. Stephen Heard : Research grant from Cook Critical Care, Inc., and Edwards Lifesciences. E. Patchen Dellinger : Research support, lectured for honoraria, or served on advisory boards for SmithKline Beecham, Wyeth-Ayerst, Pharmacia, Bristol-Myers Squibb, Zeneca, Pfizer, Aventis, Hoffamn-LaRoche, Arrow, NABI, Ortho-McNeil, Park-Davis, Abbott, ICOS, Immunex, Chiron, Searle, Ican, Inc., and Centercor. Adrienne Randolph : Reasearch support from Cook Critical Care, Inc. Leonard Mermel : Research support from Arrow; Johnson and Johnson; consultant to 3M.
PY - 2002/12
Y1 - 2002/12
N2 - Background: Although many catheter-related bloodstream infections (CR-BSIs) are preventable, measures to reduce these infections are not uniformly implemented. Objective: To update an existing evidenced-based guideline that promotes strategies to prevent CR-BSIs. Data sources: The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Studies included: Laboratory-based studies, controlled clinical trials, prospective interventional trials, and epidemiological investigations. Outcome measures: Reduction in CR-BSI, catheter colonization, or catheter-related infection. Synthesis: The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters; maximal sterile barrier precautions during central venous catheter insertion; use of a 2% chlorhexidine preparation for skin antisepsis; no routine replacement of central venous catheters for prevention of infection; and use of antiseptic/antibiotic impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (i.e. education and training, maximal sterile barrier precautions and 2% chlorhexidine for skin antisepsis). Conclusion: Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection.
AB - Background: Although many catheter-related bloodstream infections (CR-BSIs) are preventable, measures to reduce these infections are not uniformly implemented. Objective: To update an existing evidenced-based guideline that promotes strategies to prevent CR-BSIs. Data sources: The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Studies included: Laboratory-based studies, controlled clinical trials, prospective interventional trials, and epidemiological investigations. Outcome measures: Reduction in CR-BSI, catheter colonization, or catheter-related infection. Synthesis: The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters; maximal sterile barrier precautions during central venous catheter insertion; use of a 2% chlorhexidine preparation for skin antisepsis; no routine replacement of central venous catheters for prevention of infection; and use of antiseptic/antibiotic impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (i.e. education and training, maximal sterile barrier precautions and 2% chlorhexidine for skin antisepsis). Conclusion: Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection.
UR - https://www.scopus.com/pages/publications/0036909238
UR - https://www.scopus.com/pages/publications/0036909238#tab=citedBy
U2 - 10.1067/mic.2002.129427
DO - 10.1067/mic.2002.129427
M3 - Review article
C2 - 12461511
AN - SCOPUS:0036909238
SN - 0196-6553
VL - 30
SP - 476
EP - 489
JO - American Journal of Infection Control
JF - American Journal of Infection Control
IS - 8
ER -