HeatMapper: Powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics

Roel G.W. Verhaak, Mathijs A. Sanders, Maarten A. Bijl, Ruud Delwel, Sebastiaan Horsman, Michael J. Moorhouse, Peter J. van der Spek, Bob Löwenberg, Peter J.M. Valk

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Accurate interpretation of data obtained by unsupervised analysis of large scale expression profiling studies is currently frequently performed by visually combining sample-gene heatmaps and sample characteristics. This method is not optimal for comparing individual samples or groups of samples. Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata. Results: We have developed a tool called the HeatMapper that provides such visualizations in a dynamic and flexible manner and is available from http/www.erasmusmc.nl/hematologie/heatmapper/. Conclusion: The HeatMapper allows an accessible and comprehensive visualization of the results of gene expression profiling and cluster analysis.

Original languageEnglish (US)
Article number337
JournalBMC bioinformatics
Volume7
DOIs
StatePublished - Jul 12 2006

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Gene Expression Profile
Cluster analysis
Genetic Association Studies
Genotype
Transcriptome
Gene expression
Phenotype
Cluster Analysis
Visualization
Gene Expression Profiling
Multigene Family
Metadata
Profiling
Genes
Gene Expression
Integrate
Gene

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

Cite this

Verhaak, R. G. W., Sanders, M. A., Bijl, M. A., Delwel, R., Horsman, S., Moorhouse, M. J., ... Valk, P. J. M. (2006). HeatMapper: Powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics. BMC bioinformatics, 7, [337]. https://doi.org/10.1186/1471-2105-7-337

HeatMapper : Powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics. / Verhaak, Roel G.W.; Sanders, Mathijs A.; Bijl, Maarten A.; Delwel, Ruud; Horsman, Sebastiaan; Moorhouse, Michael J.; van der Spek, Peter J.; Löwenberg, Bob; Valk, Peter J.M.

In: BMC bioinformatics, Vol. 7, 337, 12.07.2006.

Research output: Contribution to journalArticle

Verhaak, RGW, Sanders, MA, Bijl, MA, Delwel, R, Horsman, S, Moorhouse, MJ, van der Spek, PJ, Löwenberg, B & Valk, PJM 2006, 'HeatMapper: Powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics', BMC bioinformatics, vol. 7, 337. https://doi.org/10.1186/1471-2105-7-337
Verhaak, Roel G.W. ; Sanders, Mathijs A. ; Bijl, Maarten A. ; Delwel, Ruud ; Horsman, Sebastiaan ; Moorhouse, Michael J. ; van der Spek, Peter J. ; Löwenberg, Bob ; Valk, Peter J.M. / HeatMapper : Powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics. In: BMC bioinformatics. 2006 ; Vol. 7.
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